WFDC2 / HE4 Antikörper

09.05.2012

Produkt-Information von WFDC2 / HE4 Antikörper

Immunogen	Recombinant Human WFDC2 / HE4 protein (Catalog#12609-H08H)
Antibody Type	Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
Clone ID	415
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	This antibody was obtained from a rabbit immunized with purified, recombinant Human WFDC2 / HE4 (rh WFDC2 / HE4; Catalog#12609-H08H; NP_006094.3; Met 1-Phe 124).

Usage Guide von WFDC2 / HE4 Antikörper

Specificity

Human WFDC2 / HE4

Immunochemistry

IHC-P: 3-10 μg/mL

WFDC2-endometrium immunohistochemistry

Immunochemical Staining of human WFDC2 in human endometrium with rabbit monoclonal antibody (5 μg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to the epithelium of uterune gland.
The left panel: tissue incubated with primary antibody;
The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).

Storage

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃.Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Hintergrund von WFDC2 / HE4 Antikörper

WAP four-disulfide core domain protein 2, also known as Epididymal secretory protein E4, Major epididymis-specific protein E4, Putative protease inhibitor WAP5, WFDC2 and HE4, is a secreted protein which contains twoWAP domains. WFDC2 / HE4 is a member of a family of stable 4-disulfide core proteins that are secreted at high levels. It is expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. It is highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis. WFDC2 may be a component of the innate immune defences of the lung, nasal and oral cavities and suggest that WFDC2 functions in concert with related WAP domain containing proteins in epithelial host defence. WFDC2 re-expression in lung carcinomas may prove to be associated with tumour type and should be studied in further detail. Mammary gland expression of tammar WFDC2 during the course of lactation showed WFDC2 was elevated during pregnancy, reduced in early lactation and absent in mid-late lactation. WFDC2 / HE4 can undergo a complex series of alternative splicing events that can potentially yield five distinct WAP domain containing protein isoforms.

References

Bingle,L. et al., 2002,Oncogene. 21 (17): 2768-73.
Hellstrom,I. et al., 2003, Cancer Res. 63 (13): 3695-700.
Bingle,L. et al., 2006, Respir Res. 7: 61.
Galgano,M.T. et al., 2006,Mod Pathol.19 (6): 847-53.
Sharp,J.A. et al., 2007, Evol Dev. 9 (4): 378-92.

Sino Biological Inc. liefert WFDC2 / HE4 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über WFDC2 / HE4 Antikörper lesen Sie bitte: http://www.sinobiological.com/WFDC2-HE4-Antibody-g-8771.html

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
WFDC2/HE4	Human	WFDC2/HE4 Protein, Recombinant	12609-H08H

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
WFDC2/HE4	WB, ELISA	WFDC2 / HE4 Antibody	12609-MM15
WFDC2/HE4	WB, ELISA	WFDC2 / HE4 Antibody	12609-RP01
WFDC2/HE4	WB, ELISA	WFDC2 / HE4 Antibody (Antigen Affinity Purified)	12609-RP02
WFDC2/HE4	WB, ELISA	WFDC2/HE4 Antibody, Mouse MAb	12609-R109
WFDC2/HE4	IHC-P	WFDC2 / HE4 Antibody	12609-R415

WFDC2 / HE4 Antikörper

Produkt-Information von WFDC2 / HE4 Antikörper

Usage Guide von WFDC2 / HE4 Antikörper

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Hintergrund von WFDC2 / HE4 Antikörper

References