DMBT1 / Muclin Antikörper

28.06.2013

Sino Biological Inc. liefert DMBT1 / Muclin Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über DMBT1 / Muclin Antikörper lesen Sie bitte:http://www.sinobiological.com/DMBT1-Muclin-Protein-Antibody-a-1169.html

Produkt-Information von DMBT1 / Muclin Antikörper

Immunogen	Recombinant Human DMBT1 / Muclin protein (Catalog#11678-H08H)
Antibody Type	Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
Clone ID	08
Ig Type	Mouse IgG1
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human DMBT1 / Muclin (rh DMBT1 / Muclin; Catalog#11678-H08H; NP_004397.2; Met 1-Ser 220). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.

Usage Guide von DMBT1 / Muclin Antikörper

Specificity	Human DMBT1 / Muclin
	No cross-reactivity in ELISA with Human cell lysate (293 cell line)
Direct ELISA	This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human DMBT1. The detection limit for Human DMBT1 is approximately 0.039 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃.Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Hintergrund von DMBT1 / Muclin Antikörper

Deleted in malignant brain tumors 1 protein, also known as glycoprotein 340, surfactant pulmonary-associated D-binding protein, DMBT1 and GP340, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB domains, 14SRCR domains and 1ZP domain. It is highly expressed in alveolar and macrophage tissues. In some macrophages, expression is detected on the membrane, and in other macrophages, it is strongly expressed in the phagosome/phagolysosome compartments. Defects in DMBT1 are involved in the development of glioma (GLM). Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. DMBT1 may be considered as a candidate tumor suppressor for brain, lung, esophageal, gastric, and colorectal cancers. It may play roles in mucosal defense system, cellular immune defense and epithelial differentiation. DMBT1 may play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. It may be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. DMBT1 may function as a binding protein in saliva for the regulation of taste sensation. It binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission.

References

Mollenhauer J. et al., 1997, Nat. Genet. 17: 32-9.
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Rosenstiel P.et al., 2007, J. Immunol. 178: 8203-11.
Stoddard E. et al., 2007, J. Immunol. 179: 3126-32.
End C. et al., 2009, Eur. J. Immunol. 39: 833-42.

Primary Antibody von Sino Biological Inc.

DMBT1 / Muclin Antikörper

Produkt-Information von DMBT1 / Muclin Antikörper

Usage Guide von DMBT1 / Muclin Antikörper

Verwandte Produkte & Themen von DMBT1 / Muclin Antikörper

Hintergrund von DMBT1 / Muclin Antikörper

References