VSIG4 Protein

16.05.2013

Sino Biological Inc. liefert VSIG4 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über VSIG4 Protein lesen Sie bitte: http://www.sinobiological.com/VSIG4-Protein-Antibody-a-701.html

Produkt-Information von VSIG4 Protein

Synonym	VSIG4, CRIg, Z39IG
Protein Construction	A DNA sequence encoding the human VSIG4 (O75144-1) (Met1-Pro283) was expressed with the Fc region of human IgG1 at the C-terminus.
Source	Human
Expression Host	Human Cells

QC Testing von VSIG4 Protein

Purity	(97.2+1.4)% as determined by SDS-PAGE	SDS-PAGE: VSIG4 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Arg 20
Molecular Mass	The recombinant human VSIG4/Fc is a disulfide-linked homodimer. The reduced monomer comprises 505 amino acids and has a predicted molecular mass of 56.2 kDa. The apparent molecular mass of the protein is approximately 57 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von VSIG4 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Verwandte Produkte & Themen von VSIG4 Protein

VSIG4 ( V-set and immunoglobulin domain containing 4 ), also known as complement receptor of the immunoglobulin superfamily (CRIg) and Z39Ig, is a type I transmembrane glycoprotein. It is a B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type I g domain and a truncated C-type I g domain. VSIG4 is abundantly expressed in several fetal tissues. In adult tissues, the highest expression of VSIG4 is in lung and placenta. It is also expressed in resting macrophages.No VSIG4 expression appears to be present in T and B cells. The specific expression of VSIG4 on resting macrophages in tissue suggests that this inhibitory ligand may be important for the maintenance of T cell unresponsiveness in healthy tissues. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation. VSIG4 is a phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. It is a potent inhibitor of the alternative complement pathway convertases.

References

Vogt L. et al., 2006, J Clin Invest. 116: 2817-26.
Helmy K. et al., 2006, Cell. 124: 915-27.
Wiesmann C. et al., 2006, Nature. 444: 217-20.
Zang X.?et al., 2006, J Clin Invest. 116: 2590-3.
Vogt L. et al.,2006, J Clin Invest. 116 (10): 2817-26.
Katschke KJ. et al., 2007, J Exp Med. 204: 1319-25.
He JQ. et al., 2008, Mol Immunol. 45: 4041-7.