USP46 Protein (N-SUMO)

Produkt-Information von USP46 Protein

QC Testing von USP46 Protein

Purity	> 90 % as determined by SDS-PAGE	SDS-PAGE: USP46 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The secreted recombinant human USP46 consists of 477 amino acids and predicts a molecular mass of 55.2 KDa. The apparent molecular mass of the protein is approximately 64 Kda in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of 20mM Tris,500mM NaCl, pH 7.4, 10%gly. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von USP46 Protein

Verwandte Produkte & Themen von USP46 Protein

Beschreibung von USP46 Protein

USP46 is a member of the peptidase C19 family, USP12/USP46 subfamily. USP46 is a deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. Deubiquitinating enzymes (DUBs) are a large group of proteases which are also commonly referred to as deubiquitinating peptidases, deubiquitinating isopeptidases, deubiquitinases, ubiquitin proteases, ubiquitin hydrolyases, ubiquitin isopeptidases, or Dubs. They regulate ubiquitin-dependent metabolic pathways by cleaving ubiquitin-protein bonds. They also may act as negative and positive regulators of the ubiquitin system. USP46 is broadly expressed. It may act by mediating the deubiquitination of GAD1/GAD67. USP46 has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity and it is not involved in deubiquitination of monoubiquitinated FANCD2.

References

1. Joo HY. et al., 2011, J Biol Chem. 286 (9): 7190-201.
2. Kushima I. et al., 2010, J Hum Genet. 55 (3): 133-6.
3. Cohn MA. et al., 2009, J Biol Chem. 284 (8): 5343-51.

Sino Biological Inc. liefert USP46 Protein (N-SUMO) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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