CANT1 Protein

Produkt-Information von CANT1 Protein

QC Testing von CANT1 Protein

Purity	> 90 % as determined by SDS-PAGE	SDS-PAGE: CANT1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu
Molecular Mass	The recombinant human CANT1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 582 amino acids and has a predicted molecular mass of 64.3 kDa. The apparent molecular mass of the protein is approximately 65 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CANT1 Protein

Verwandte Produkte & Themen von CANT1 Protein

Enzyme>>Other>> CANT1

Beschreibung von CANT1 Protein

CANT1(calcium activated nucleotidase 1, N-Histidine-tagged) belongs to the apyrase family. It functions as a calcium-dependent nucleotidase with a preference for UDP. Alternatively spliced transcript variants have been noted for this gene. Defects in CANT1 are the cause of desbuquois dysplasia. A chondrodysplasia characterized by severe prenatal and postnatal growth retardation (less than -5 SD), joint laxity, short extremities, progressive scoliosis, round face, midface hypoplasia, prominent bulging eyes. The main radiologic features are short long bones with metaphyseal splay, a 'Swedish key' appearance of the proximal femur (exaggerated trochanter), and advance carpal and tarsal bone age. Two forms of desbuquois dysplasia are distinguished on the basis of the presence (type 1) or absence (type 2) of characteristic hand anomalies: an extra ossification center distal to the second metacarpal, delta phalanx, bifid distal thumb phalanx, and phalangeal dislocations.

References

1. Failer BU. et al., 200, J Biol Chem. 277 (40): 36978-86.
2. Smith TM et al., 2002, Arch Biochem Biophys. 406 (1): 105-15.
3. Strausberg RL. et al., 2003, Proc Natl Acad Sci. 99 (26): 16899-903.

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