UBASH3B Protein (His Tag)

22.04.2013

Sino Biological Inc. liefert UBASH3B Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über UBASH3B Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/UBASH3B-Sts1-TULA-2-Protein-Antibody-a-5844.html

Produkt-Information von UBASH3B Protein

Synonym	UBASH3B, KIAA1959, STS1
Protein Construction	A DNA sequence encoding the mature form of human UBASH3B(Q8TF42) (Gln382-Glu649) was expressed with a polyhistide tag at the N-terminus.
Source	Human
Expression Host	E.coli

QC Testing von UBASH3B Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: UBASH3B protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant human UBASH3B consists of 283 amino acids and predicts a molecular mass of 32 KDa. It migrates as an approximately 30 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von UBASH3B Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von UBASH3B Protein

UBASH3B contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. UBASH3B was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. UBASH3B interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. It promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. UBASH3B exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.

References

Maruyama K. et al., 1994, Gene. 138 (1-2): 171-4.
Carpino N. et al., 2002, Mol Cell Biol. 22 (21): 7491-500.
Nagase T. et al., 2002, DNA Res. 8 (6): 319-27.

UBASH3B (Sts1,TULA-2) related areas, pathways, and other information