UBASH3A (aa 354-623) Protein (His Tag)

18.04.2013

Sino Biological Inc. liefert UBASH3A (aa 354-623) Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über UBASH3A (aa 354-623) Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/UBASH3A-Protein-Antibody-a-5857.html

Produkt-Information von UBASH3A Protein

Synonym	UBASH3A, STS2
Protein Construction	A DNA sequence encoding the mature form of human UBASH3A (AAH69511.1) (Ala354-Asn623) was expressed with a polyhistide tag at the N-terminus.
Source	Human
Expression Host	E.coli

QC Testing von UBASH3A Protein

Purity	> 90 % as determined by SDS-PAGE	SDS-PAGE: UBASH3A protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant human UBASH3A consists of 286 amino acids and predicts a molecular mass of 32.2 KDa. It migrates as an approximately 30 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von UBASH3A Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von UBASH3A Protein

UBASH3A is a member of the T-cell ubiquitin ligand (TULA) family. This family consists of two members. Both of them can negatively regulate T-cell signaling. UBASH3A can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of UBASH3A gene results in multiple transcript variants. It interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. UBASH3A promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. UBASH3A also exhibits negligigle protein tyrosine phosphatase activity at neutral pH. It may act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. It may also inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.

References

Collingwood TS. et al., 2007, J Biol Chem. 282 (42): 30920-8.
Smirnova EV. et al., 2008, Virology. 372 (1): 10-23.
Wattenhofer M. et al., 2001, Hum Genet. 108 (2): 140-7.
UBASH3A related areas, pathways, and other information