TSPAN1 (aa 110-211) Protein

10.04.2013

Sino Biological Inc. liefert TSPAN1 (aa 110-211) Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über TSPAN1 (aa 110-211) Protein lesen Sie bitte: http://www.sinobiological.com/TSPAN1-Protein-Antibody-a-5770.html

Produkt-Information von TSPAN1 Protein

Synonym	TSPAN1
Protein Construction	A DNA sequence encoding the human TSPAN1 (O60635)(Tyr110-Asn211) was expressed with the Fc region of rabbit IgG at the N-terminus.
Source	Human
Expression Host	Human Cells

QC Testing von TSPAN1 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: TSPAN1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ser
Molecular Mass	The recombinant human TSPAN1 comprises 351 amino acids and has a predicted molecular mass of 39.1 kDa. The apparent molecular mass of the protein is approximately 43-53 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von TSPAN1 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von TSPAN1 Protein

TSPAN1 belongs to the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins have four hydrophobic domains, intracellular N- and C-termini and two extracellular domains. Tetraspanins act as scaffolding proteins, anchoring multiple proteins to one area of the cell membrane. They also mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TSPAN1 interacts with human thiamine transporter-1 (hTHTR-1). HTHTR-1 contributes to intestinal thiamine uptake, and its function is regulated at both the transcriptional and posttranscriptional levels. TSPAN1 and hTHTR-1 colocalize in human intestinal epithelial HuTu-80 cells. Coexpression of TSPAN1 in these cells led to a significant decrease in the rate of degradation of hTHTR-1 compared with cells expressing the hTHTR-1 alone; in fact the half-life of the TSPAN1 protein was twice longer in the former cell type compared with the latter cell type.

References

Chen L. et al., 2010, J Korean Med Sci. 25 (10): 1438-42.
Chen L. et al., 2010, Tumori. 96 (5): 744-50.
Nabokina SM. et al., 2011, Am J Physiol Gastrointest Liver Physiol. 301 (5): G808-13.

TSPAN1 related areas, pathways, and other information