LFA-3 / CD58 Protein

10.04.2013

Sino Biological Inc. liefert LFA-3 / CD58 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über LFA-3 / CD58 Protein lesen Sie bitte: http://www.sinobiological.com/LFA-3-CD58-Protein-Antibody-a-5769.html

Produkt-Information von LFA-3 / CD58 Protein

Synonym	CD58
Protein Construction	A DNA sequence encoding the human CD58 (Q9BRW0) (Met1-Arg215) was expressed with the Fc region of human IgG1 at the C-terminus.
Source	Human
Expression Host	Human Cells

QC Testing von LFA-3 / CD58 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: LFA-3 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Phe 29
Molecular Mass	The recombinant human CD58/Fc is a disulfide-linked homodimer. The reduced monomer comprises 428 amino acids and has a predicted molecular mass of 48.5 kDa. The apparent molecular mass of the protein is approximately 68 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von LFA-3 / CD58 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von LFA-3 / CD58 Protein

CD53 is a member of the transmembrane 4 superfamily, also called the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. These proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD53 is a cell surface glycoprotein that is known to complex with integrins. Familial deficiency of CD53 gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. CD53 contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation.

References

Rochelle JM. et al., 1993, Int Immunol. 5 (2): 209-16.
Virtaneva KI. et al., 1993, Immunogenetics. 37 (6): 461-5.
Horejsí V. et al., 1991, FEBS Lett. 288 (1-2): 1-4.

LFA-3 (CD58) related areas, pathways, and other information