TMEM25 Protein (His Tag)

10.04.2013

Sino Biological Inc. liefert TMEM25 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über TMEM25 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/TMEM25-Protein-a-5763.html

Produkt-Information von TMEM25 Protein

Synonym	TMEM25
Protein Construction	A DNA sequence encoding the human TMEM25 (AAH51841.1) (Met1-Pro224) was expressed with a polyhistidine tag at the C-terminus.
Source	Human
Expression Host	Human Cells

QC Testing von TMEM25 Protein

Purity	> 95% as determined by SDS-PAGE	SDS-PAGE: TMEM25 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu 27
Molecular Mass	The recombinant human TMEM25 consists of 209 amino acids and predicts a molecular mass of 22.8 KDa. It migrates as an approximately 43 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von TMEM25 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von TMEM25 Protein

TMEM25 is a novel member of the immunoglobulin superfamily. Immunoglobulin superfamily members are implicated in immune responses, growth factor signaling, and cell adhesion. TMEM25 contains 1 Ig-like (immunoglobulin-like) domain and is a target of pharmacogenomics in the field of oncology and regenerative medicine. TMEM25 isoform 1, consisting of exons 1-9, encoded a 366-aa transmembrane protein. TMEM25 isoform 2, consisting of exons 1-4 and 6-9, encoded a 322-aa secreted protein. TMEM25 mRNA was expressed in brain, including cerebellar cortex and hippocampus, as well as in neuroblastoma, brain tumors, and gastric cancer. Human TMEM25 gene was located at the 11q23.3 oncogenomic recombination hotspot around the MLL amplicon and the neuroblastoma deleted region.

References

Grouse LH. et al., 2003, Proc Natl Acad Sci. 99 (26): 16899-903.
Suzuki Y. et al., 1997, Gene. 200 (1-2): 149-56.
Sugano S. et al., 1994, Gene. 138 (1-2): 171-4.
Katoh M. et al., 2004, Oncol Rep. 12 (2): 429-33.

TMEM25 related areas, pathways, and other information