TROP2 / TACSTD2 Antikörper

22.05.2012

Produkt-Information von TROP2 / TACSTD2 Antikörper

Immunogen	Recombinant Human TROP2 / TACSTD2 protein (Catalog#10428-H08H)
Antibody Type	Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
Clone ID	001
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	This antibody was obtained from a rabbit immunized with purified, recombinant Human TROP2 / TACSTD2 (rh TROP2 / TACSTD2; Catalog#10428-H08H; NP_002344.2; Met 1-Thr 274).

Usage Guide von TROP2 / TACSTD2 Antikörper

Specificity

Human TROP2 / TACSTD2

Has cross-reactivity in ELISA with

Human E-cad

Human CD146

Human CD171

Human BCAM

Human ICAM1

No cross-reactivity in ELISA with

Human VCAM1

Immunochemistry

ICC/IF: 5-15 μg/mL

TROP2-R001-5ug-MCF-7-IF Immunofluorescence

Immunofluorescence staining of human TROP2 in MCF-7 cells with rabbit monoclonal antibody (5 μg/mL). The image showing membrane staining of MCF-7 cells.

Western blot

This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human TROP2 in WB.

Direct ELISA

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human TROP2.

Storage

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃.Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von TROP2 / TACSTD2 Antikörper

Related Areas:

Stem Cell>>Embryonic Stem Cell (ESC)>>Embryonic Stem Cell Marker>>TROP-2/TACSTD2

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>TROP-2/TACSTD2

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
TROP-2/TACSTD2	Human	TROP2/TACSTD2/Fc Protein, Recombinant	10428-H03H
TROP-2/TACSTD2	Human	TROP2/TACSTD2 Protein, Recombinant	10428-H08H
TROP-2/TACSTD2	Mouse	TROP2 / TACSTD2 Protein, Recombinant	50922-M02H
TROP-2/TACSTD2	Mouse	TROP2 / TACSTD2 Protein, Recombinant	50922-M08H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human TROP-2/TACSTD2	ELISA	Mouse Monoclonal Antibody	10428-MM01
Human TROP-2/TACSTD2	WB	Mouse Monoclonal Antibody	10428-MM02
Human TROP-2/TACSTD2	WB	Mouse Monoclonal Antibody	10428-MM01-F
Human TROP-2/TACSTD2	WB, ELISA	TROP2 / TACSTD2 Antibody	10428-R001
Human TROP-2/TACSTD2	WB, ELISA	TROP-2/TACSTD2 Antibody, Rabbit MAb	10428-R030
Human TROP-2/TACSTD2	WB, ELISA	Rabbit Polyclonal Antibody	10428-RP01
Human TROP-2/TACSTD2	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10428-RP02

Hintergrund von TROP2 / TACSTD2 Antikörper

TROP2, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed by human carcinomas. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate. The cytoplasmic tail of TROP2 possesses potential serine and tyrosine phosphorylation sites and a conserved phosphatidyl-inositol binding consensus sequence. TROP2 transduces an intracellular calcium signal and acts as a cell surface receptor, meanwhile is involved in the regulation of cell- cell adhesion. Accordingly, as a widespread stimulator of human cancer growth and a unique marker and causal factor of metastatic cancer, TROP2 is a possible candidate for diagnosis and molecular target therapy. Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.

References

Fornaro, M. et al., 1995, Int. J. Cancer. 62: 610-618.
Ripani, E. et al., 1998, Int. J. Cancer. 76: 671-676.
Linnenbach, A.J. et al., 1993, Mol. Cell. Biol. 13: 1507-1515.
Ohmachi, T. et al., 2006, Clin. Cancer. Res. 12: 3057-3063.
Tsujikawa, M. et al., 1999, Nat. Genet. 21: 420-423.

Sino Biological Inc. liefert TROP2 / TACSTD2 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über TROP2 / TACSTD2 Antikörper lesen Sie bitte: http://www.sinobiological.com/TROP2-TACSTD2-Antibody-g-8866.html