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| Immunogen | Recombinant Human CD16-2 / FCGR4 protein (Catalog#50036-M08H) |
| Antibody Type | Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform ) |
| Clone ID | 011 |
| Ig Type | Rabbit IgG |
| Formulation | 0.2 μm filtered solution in PBS with 5% trehalose |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD16-2 / FCGR4 (rM CD16-2 / FCGR4; Catalog#50036-M08H; NP_653142.2; Met 1-Gln 203). |
| Specificity | Mouse CD16-2 / FCGR4 | |||||
| Has cross-reactivity in ELISA with Human CD64 No cross-reactivity in ELISA withHuman CD16a Human CD16b Human CD32a Human CD32b Mouse FCGR3 | ||||||
| Immunochemistry | IHC-P: 5-15 μg/mL
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| Western blot | This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse FCGR4 in WB. | |||||
| Direct ELISA | This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse FCGR4. | |||||
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃.Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. |
Receptors for the Fc region of IgG (Fc γ Rs) constitute a subfamily of the Ig superfamily, and function in the activation or inhibition of immune responses. Based on close relationships in their extracellular domains, the Fc γ R have been divided into three classes designated as Fc γ RI (CD64), Fc γ RII (CD32), and Fc γ RIII (CD16). Human CD16 is encoded by two genes: Fc γ RIIIA and Fc γ RIIIB, and the newly described mouse FCGR4, also referred to as CD16-2, has been proposed to be the mouse homolog of human Fc γ RIIIA because of high sequence homology (60 % aa identity). FCGR4 is expressed in peripheral blood leukocytes, spleen, thymus, colon and intestine, and serves as an activating receptor for IgG2a and IgG2b via association with an ITAM bearing accessory protein. Although mouse FCGR4 functioned as a low-affinity IgE receptor for all IgE allotypes, ligation of FCGR4 by antigen-IgE (b) immune complexes promotes macrophage-mediated phagocytosis, presentation of antigen to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions.
Sino Biological Inc. liefert CD16-2 / FCGR4 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.
Weitere Informationen über CD16-2 / FCGR4 Antikörper lesen Sie bitte: http://www.sinobiological.com/CD16-2-FCGR4-Antibody-g-9037.html
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