TrkA / NTRK1 Antikörper

29.06.2012

Produkt-Information von TrkA / NTRK1 Antikörper

Immunogen	Recombinant Human TrkA / NTRK1 protein (Catalog#10222-H08H)
Antibody Type	Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
Clone ID	024
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	This antibody was obtained from a rabbit immunized with purified, recombinant Human TrkA / NTRK1 (rh TrkA / NTRK1; Catalog#11073-H08H; NP_002520.2; Met 1-Pro 382).

TrkA / NTRK1 Antibody Usage Guide

Specificity

Human TrkA / NTRK1

Immunochemistry

IHC-P 5-20 μg/mL

NTRK1-brain immunohistochemistry

Immunochemical staining of human NTRK1 in human brain with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
The left panel: tissue incubated with primary antibody;
The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).

Storage

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von TrkA / NTRK1 Antikörper

Related Areas:

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>TrkA/NTRK1

Neuroscience>>Neurotrophic Factor & Receptor>>Neurotrophin & Receptor>>TrkA/NTRK1

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>TrkA/NTRK1

Cancer>>Growth Factor & Receptor>> Neurotrophin & Receptor>>TrkA/NTRK1

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>TrkA/NTRK1

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
TrkA/NTRK1	Human	TrkA/NTRK1/Fc Protein, Recombinant	11073-H03H
TrkA/NTRK1	Human	TrkA/NTRK1 Protein (aa 194-413), Recombinant	11073-H07H2
TrkA/NTRK1	Human	TrkA/NTRK1 Protein (aa 285-413), Recombinant	11073-H07E1
TrkA/NTRK1	Human	TrkA/NTRK1 Protein, Recombinant	11073-H08H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human TrkA/NTRK1	WB, ELISA	Mouse Monoclonal Antibody	11073-MM04
Human TrkA/NTRK1	WB, ELISA	Mouse Monoclonal Antibody	11073-MM09
Human TrkA/NTRK1	WB, ELISA	TrkA/NTRK1 Antibody, Rabbit MAb	11073-R001
Human TrkA/NTRK1	IHC-P	TrkA / NTRK1 Antibody	11073-R024
Human TrkA/NTRK1	WB, ELISA	Rabbit Polyclonal Antibody	11073-RP01
Human TrkA/NTRK1	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	11073-RP02

Hintergrund von TrkA / NTRK1 Antikörper

Neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), also well known as TrkA, is a member of the neurotrophic tyrosine kinase receptor family belonging to Tyr protein kinase superfamily, which also includes TrkB and TrkC. TrkA/NTRK1 has a complex subdomain orgnazation conserved in the family members, containing two cysteine-rich domains, a cluster of three leucine-rich motifs (LRR), and two Ig-like C2-type domains in the extracellular region, as well as an tyrosine kinase domain in the cytoplasmic region. TrkA/NTRK1 exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures, and is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). TrkA/NTRK1 plays an important role in cell survival, differentiation, and apoptosis in various neuronal and nonneuronal cell types, especially in the nervous system by recruiting signaling molecules including SHC1, PI 3-kinase, and PLC-gamma-1 that activate pathways required for the growth and survival of neurons. It has been shown that TrkA/NTRK1 is specially involved in the development and function of the nociceptive reception system and establishment of thermal regulation via sweating. Two distinct TrkA/NTRK1 isoforms have been identified: TrkA-II is primarily expressed in neuronal cells, while isoform TrkA-I is found in non-neuronal tissues. Defects in TrkA/NTRK1 are a cause of a rare autosomal recessive disorder, congenital insensitivity to pain with anhidrosis (CIPA).

References

Bossemeyer. D. et al., 1989, J. Biol. Chem. 264:16403-16410.
Varsano,T. et al., 2006, Mol. Cell. Biol. 26: 8942-8952.
Perrone, L. et al., 2005, Biochem J. 385: 233-241.
Holtzman,D.M. et al., 2009, J. Neurosci. 15: 1567-1576.
Dan C. Lin et al., 2006,Mol Cell Biol. 26: 8928-8941.
Jung, E.J. et al., 2008, Exp. Mol. Med. 40: 276-285.

Sino Biological Inc. liefert TrkA / NTRK1 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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