IL-1RA Antikörper ( FITC )

Produkt-Information von IL-1RA Antikörper

Usage Guide von IL-1RA Antikörper

Specificity	Human IL-1RA
	No cross-reactivity in ELISA with Human IL1R4 Human SIGIRR Human IL1b Human IL1R2 Human IL1R1 MouseIL1A Mouse IL1β
Flow Cytometry	The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and then stained with FITC Rabbit anti-IL1ra (10123-R004-F). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. Flow cytometric analysis of Human IL1ra expression in A431 cells. Flow cytometry was performed on a BD FACSCalibur flow cytometry system Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human IL1RA in WB.
Storage	This antibody is stable for 12 months from date of receipt when stored at 2℃- 8℃. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Verwandte Produkte & Themen von IL-1RA Antikörper

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-1RA/IL-1F3

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-1 superfamily and IL-1R/TLR family >>IL-1RA/IL-1F3

Hintergrund von IL-1RA Antikörper

IL1 is an important prototypic pro-inflammatory cytokine that affects multiple cell types, often in concert with another cytokine, tumor necrosis factor (TNF). There are two forms of IL1, IL1α. and IL1β, whose function are mediated by the two specific receptors on the cell surfaces. The IL1 receptor antagonist (IL1RA), formerly called the IL1 inhibitor, is a member of the IL1 cytokine family which binds to the same receptor (IL1R) as IL1, and thus prevents IL1 from signal transduction without interaction with the IL1 molecules. In terms of protein similarities,IL1RA is more closely related to IL1β than it is to IL1α. IL1RA modulates a variety of IL1-related immune and inflammatory responses, and accordingly, the balance between IL1 and IL1Ra in local tissues plays an important role in the susceptibility to and severity of many diseases. IL1RA is suggested to have possible therapeutic applications in treatment of sepsis, rheumatoid arthritis, and chronic myelogenous leukemia. Four alternatively spliced transcript variants encoding distinct isoforms have been identified, and the isoform 1 of IL1RA is secreted from monocytes, macrophages, neutrophils, and other cells.

References

1. Haskill, S. et al., 1991, Proc. Natl. Acad. Sci. USA. 88: 3681-3685.
2. Sehouli, J. et al., 2002, Anticancer. Res. 22: 3421-3424.
3. Arend, W.P. e t al., 1998, Annu. Rev. Immunol. 16: 27-55.
4. Dinarello, C.A. et al., 1997, Cytokine. Growth. Factor. Rev. 8: 253-265.

Sino Biological Inc. liefert IL-1RA Antikörper ( FITC ) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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