TPT1 / Tumor protein Protein (His Tag)

14.05.2013

Sino Biological Inc. liefert TPT1 / Tumor protein Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über TPT1 / Tumor protein Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/TCTP-TPT1-Protein-Antibody-a-5929.html

Produkt-Information von TPT1 / Tumor protein Protein

Synonym	TPT1
Protein Construction	A DNA sequence encoding the human TPT1 (Met1-Cys172) was expressed with a polyhistidine tag at the N-terminus.
Source	Human
Expression Host	E.coli

QC Testing von TPT1 / Tumor protein Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: TPT1 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant human TPT1 consists of 187 amino acids and predicts a molecular mass of 21.4 KDa. It migrates as an approximately 23 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von TPT1 / Tumor protein Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von TPT1 / Tumor protein Protein

Tumor protein, also known as TPT1, is a highly conserved protein among many eukaryotic organisms. Tumor protein is involved in a variety of cellular activities, including microtubule stabilization, calcium-binding activities, and apoptosis. The Mammalian translationally controlled tumour protein (TPT1) (or P23) is a protein which has been found to be preferentially synthesised in cells during the early growth phase of some types of tumour, but which is also expressed in normal cells. It was first identified as a histamine-releasing factor, acting in IgE +-dependent allergic reactions. In addition, TPT1 has been shown to bind to tubulin in the cytoskeleton, has a high affinity for calcium, is the binding target for the antimalarial compound artemisinin, and is induced in vitamin D-dependent apoptosis. TPT1 production is thought to be controlled at the translational as well as the transcriptional level.

References

Thaw P. et al., 2001, Nat Struct Biol. 8 (8): 701-4.
Thiele H. et al., 2000, Eur J Biochem. 267 (17): 5473-81.
Chitpatima ST. et al., 1988, Nucleic Acids Res. 16 (5): 2350.