TPM4 / Tropomyosin 4 Protein (His Tag)

27.05.2013

Sino Biological Inc. liefert TPM4 / Tropomyosin 4 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über TPM4 / Tropomyosin 4 Protein (His Tag) lesen Sie bitte:http://www.sinobiological.com/TPM4-tropomyosin-4-Protein-Antibody-a-6225.html

Produkt-Information von TPM4 / Tropomyosin 4 Protein

Synonym	TPM4
Protein Construction	A DNA sequence encoding the human TPM4 (P67936) (Ala2-Ile248) was expressed with an N-terminal polyhistidine tag.
Source	Human
Expression Host	Human Cells

QC Testing von TPM4 / Tropomyosin 4 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: TPM4 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant human TPM4 comprises 267 amino acids and has a predicted molecular mass of 30.8 kDa. The apparent molecular mass of the protein is approximately 35-40 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von TPM4 / Tropomyosin 4 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von TPM4 / Tropomyosin 4 Protein

TPM4, also known as tropomyosin 4, is a member of the tropomyosin family. Members of this family are actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. TPM4 is expressed in cardiac tissue and platelets. It is highly expressed in the platelets of hypertensive patients. TPM4 plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells it is implicated in stabilizing cytoskeleton actin filaments.

References

Udeshi ND. et al., 2012, Mol Cell Proteomics. 11 (5): 148-59.
Rostila A. et al., 2012, Lung Cancer. 77 (2): 450-9.
Vlahovich N. et al., 2008, Cell Motil Cytoskeleton. 65 (1): 73-85.