TNFRSF19 / TROY Protein

25.12.2012

Sino Biological Inc. liefert TNFRSF19 / TROY Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über TNFRSF19 / TROY Protein lesen Sie bitte: http://www.sinobiological.com/TNFRSF19-TROY-Protein-g-10186.html

Produkt-Information von TNFRSF19 / TROY Protein

Synonym	TNFRSF19, TAJ, TROY
Protein Construction	A DNA sequence encoding the human TNFRSF19 (Q9NS68-2) (Met1-Leu170) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Source	Human
Expression Host	Human Cells

QC Testing von TNFRSF19 / TROY Protein

Purity	> 85 % as determined by SDS-PAGE	SDS-PAGE: TNFRSF19 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu 30
Molecular Mass	The recombinant human TNFRSF19/Fc is a disulfide-linked homodimer. The reduced monomer comprises 382 amino acids and has a predicted molecular mass of 42.5 kDa. The apparent molecular mass of the protein is approximately 52-57 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von TNFRSF19 / TROY Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Verwandte Produkte & Themen von TNFRSF19 / TROY Protein

Related Areas:

Stem Cell>>Neural Stem Cell (NSC)>>Glial Cell Markers>>TNFRSF19/TROY

Immunology>>Cytokine & Receptor>>TNF Superfamily>>TNFRSF19/TROY

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
TNFRSF19/TROY	Human	TNFRSF19 / TROY Protein, Recombinant	13387-H02H
TNFRSF19/TROY	Mouse	TNFRSF19/TROY Protein, Recombinant	50148-M03H
TNFRSF19/TROY	Mouse	TNFRSF19/TROY Protein, Recombinant	50148-M08H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Mouse TNFRSF19/TROY	WB, ELISA	TNFRSF19/TROY Antibody, Rabbit PAb	50148-RP01
Mouse TNFRSF19/TROY	WB, ELISA	TNFRSF19/TROY Antibody, Rabbit PAb (Antigen Affinity Purified)	50148-RP02
Mouse TNFRSF19/TROY	WB, ELISA	TNFRSF19 / TROY Antibody	50148-R208

Beschreibung von TNFRSF19 / TROY Protein

Tumor necrosis factor receptor superfamily member 19, also known as, Toxicity and JNK inducer, TNFRSF19, TRADE and Troy, is a member of the TNF-receptor superfamily and contains 3 TNFR-Cys repeats. TNFRSF19 is highly expressed in adult brain, and in embryos from day 11-17, but not earlier. It is detected in embryonic brain and epithelium, and at lower levels in adult heart, lung and liver. In neonatal mice, TNFRSF19 is mainly expressed in hair follicles and neuron-like cells in the cerebellum, but not in the skin epidermis. TNFRSF19 has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. TNFRSF19 is the first TNFRSF member that is identified as a biomarker for melanoma. TNFRSF19 also presents a potentially novel cell surface signaling target for inhibitors, cell and/or antibody-based immunotherapies.

References

Hu S. et al., 1999, Genomics. 62: 103-7.
Eby MT. et al., 2000, J Biol Chem. 275: 15336-42.
Kojima T. et al., 2000, J Biol Chem. 275: 20742-7.
Spanjaard RA. et al., 2007, Int J Cancer. 120 (6): 1304-10.