TETHERIN / BST2 / CD317 Protein

Sino Biological Inc. liefert TETHERIN / BST2 / CD317 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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Produkt-Information von TETHERIN / BST2 / CD317 Protein

QC Testing von TETHERIN / BST2 / CD317 Protein

Purity	> 90 % as determined by SDS-PAGE	SDS-PAGE: TETHERIN protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu
Molecular Mass	The recombinant human BST2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 372 amino acids and has a predicted molecular mass of 41 kDa. The apparent molecular mass of the protein is approximately 51 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von TETHERIN / BST2 / CD317 Protein

Verwandte Produkte & Themen von TETHERIN / BST2 / CD317 Protein

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>BST2/CD317

Beschreibung von TETHERIN / BST2 / CD317 Protein

Tetherin also known as bone marrow stromal antigen 2 and BST2 is single-pass type Ⅱ membrane protein with an extracellular coiled coil domain forms a long semi-flexible rod-like structure important for virion retention at the cell surface and prevention of virus spreading. BST2 predominantly expressed in liver, lung, heart and placenta and low levels in pancreas, kidney, skeletal muscle and brain. This protein is found overexpressed in multiple myeloma cells. It is highly expressed during B-cell development, from pro-B precursors to plasma cells, and on T-cells, monocytes, NK cells and dendritic cells. BST2 is involved in the sorting of secreted proteins and in pre-B cell growth. As an antiretroviral defense protein, BST2 blocks release of enveloped virus from the cell surface. Active against at least four virus families: retroviruses, filoviruses, arenaviruses, and herpesviruses. BST2 is discovered as an inhibitor to HIV-1 infection in the absence of Vpu and it inhibits the release of other viruses such as the Lassa and Marburg virions.

References

1. Ishikawa J. et al., 1995, Genomics. 26 (3): 527-34.
2. Viswanathan K. et al., 2011, PLoS Pathog. 7 (11): 10023-32.
3. Gifford RJ. 2011, Hum Mutat. 32 (11).