ROR1 (aa 453-783) Protein (GST Tag)

11.04.2013

Sino Biological Inc. liefert ROR1 (aa 453-783) Protein (GST Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über ROR1 (aa 453-783) Protein (GST Tag) lesen Sie bitte: http://www.sinobiological.com/ROR1-Protein-Antibody-a-5771.html

Produkt-Information von ROR1 Protein

Synonym	ROR1, NTRKR1
Protein Construction	A DNA sequence encoding the human ROR1 (AAA60275.1) (Met453-Asn783) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Source	Human
Expression Host	Baculovirus-Insect cells

QC Testing von ROR1 Protein

Purity	> 90 % as determined by SDS-PAGE	SDS-PAGE: ROR1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant human ROR1/GST chimera consists of 568 amino acids and has a calculated molecular mass of 65.3 kDa. The recombinant protein migrates approximately 63 kDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile 20mM Tris, 500mM NaCl, 2mM GSH, 3mM DTT, 10% glycerol, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von ROR1 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von ROR1 Protein

ROR1 is an enzyme that in humans is encoded which belongs to the receptor tyrosine kinase-like orphan receptor (ROR) family. RORs are a family of tyrosine kinase receptors that are important in regulating skeletal and neuronal development, cell migration and cell polarity. ROR1 is a glycosylated type I membrane protein. ROR1 modulates neurite growth in the central nervous system. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. ROR1 gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.

References

Nomi M. et al., 2001, Mol Cell Biol. 21 (24): 8329-35.
Hofer T. et al., 2008, Clin Cancer Res. 14 (2): 396-404.
Behm FM. et al., 2009, Mol Med. 16 (7-8): 247-53.
Allen C. et al., 1997, Genomics. 41 (2): 283-5.

ROR1 related areas, pathways, and other information