TGFBR3 / Betaglycan Protein (His Tag)

13.06.2013

Sino Biological Inc. liefert TGFBR3 / Betaglycan Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über TGFBR3 / Betaglycan Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/TGFBR3-Protein-a-2459.html

Produkt-Information von TGFBR3 / Betaglycan Protein

Synonym	TGFBR3
Protein Construction	A DNA sequence encoding the human TGFBR3 (Q03167-1) (Met 1-Gly781) was expressed with a C-terminal polyhistidine tag.
Source	Human
Expression Host	Baculovirus-Insect cells

QC Testing von TGFBR3 / Betaglycan Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE TGFBR3 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The secreted recombinant human TGFBR3 consists of 791 amino acids and predicts a molecular mass of 87.8 KDa. The apparent molecular mass of the protein is approximately 88 KDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von TGFBR3 / Betaglycan Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von TGFBR3 / Betaglycan Protein

Transforming growth factor beta receptor type 3, also known as TGF-beta receptor type 3, TGFR-3, Transforming growth factor beta receptor III, Betaglycan, TGF-beta receptor type III and TGFBR3, is a single-pass type I membrane protein. TGFBR3 / Betaglycan is known to be expressed in adult testis and ovary. TGFBR3 / Betaglycan was expressed within the fetal testis interstitium, predominantly by Leydig cells, but expression shifted inside the seminiferous cords at birth. TGFBR3 / Betaglycan was detected in both the somatic and germ cell lineages in the fetal and neonatal ovary. This differential expression pattern suggests divergent roles for this TGFBR3 in developing testis and ovary. TGFBR3 / Betaglycan is the TGF-beta component most commonly downregulated among localized human prostate cancer. TGFBR3 / Betaglycan downregulation is an important step in prostate tumorigenesis. TGFBR3 / Betaglycan is an accessory receptor that binds to and modulates the activities of both transforming growth factor-beta (TGFbeta) and inhibin, two members of the TGFbeta superfamily of growth factors that regulate many aspects of reproductive biology.

References

Sharifi N. et al., 2007, Prostate. 67 (3):301-11.
Sarraj M.A. et al., 2007, Growth Factors. 25 (5): 334-45.
Xiong D.H. et al., 2009, Am J Hum Genet. 84 (3): 388-98.
Sarraj MA. et al., 2010, Biol Reprod. 82 (1): 153-62.