KIR2DL4 / CD158D Protein

13.06.2013

Sino Biological Inc. liefert KIR2DL4 / CD158D Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über KIR2DL4 / CD158D Protein lesen Sie bitte:http://www.sinobiological.com/KIR2DL4-CD158d-Protein-Antibody-a-6235.html

Produkt-Information von KIR2DL4 / CD158D Protein

Synonym	KIR2DL4, CD158D, KIR103AS
Protein Construction	A DNA sequence encoding the human KIR2DL4 (ADY38409.1)(Met1-His242) was expressed with the Fc region of human IgG1 at the C-terminus.
Source	Human
Expression Host	CHO Stable Cells

QC Testing von KIR2DL4 / CD158D Protein

Purity	(75.1+13.2+10.1)% as determined by SDS-PAGE	SDS-PAGE: KIR2DL4 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Trp 24
Molecular Mass	The recombinant human KIR2DL4/Fc is a disulfide-linked homodimer. The reduced monomer comprises 462 amino acids and has a predicted molecular mass of 51.3 kDa. The apparent molecular mass of the protein is approximately 62, 34 and 32 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von KIR2DL4 / CD158D Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von KIR2DL4 / CD158D Protein

KIR2DL4, also known as CD158d, is a member of the killer cell Ig-like receptor (KIR) family. KIRs are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of KIR2DL4 was sensitive to inhibition by another ITIM-containing receptor. The activation-deficient mutant of KIR2DL4 inhibited the signal delivered by the activating receptor CD16.

References

Selvakumar A. et al., 1997, Tissue Antigens. 48 (4 Pt 1): 285-94.
Selvakumar A. et al., 1997, Immunol Rev. 155: 183-96.
Selvakumar A. et al., 1997, Tissue Antigens. 49 (6): 564-73.