TBCA Protein (Native)

27.11.2012

Sino Biological Inc. liefert TBCA Protein (Native) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über TBCA Protein (Native) lesen Sie bitte: http://www.sinobiological.com/TBCA-Protein-g-9915.html

Produkt-Information von TBCA Protein

Synonym	TBCA
Protein Construction	A DNA sequence encoding the mature form of human TBCA (O75347) (Met1-Ala108) was expressed, with a N-terminal Met.
Source	Human
Expression Host	E.coli

QC Testing von TBCA Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: TBCA protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant human TBCA consists of 109 amino acids and predicts a molecular mass of 13 KDa. It migrates as an approximately 16 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.5. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von TBCA Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von TBCA Protein

Tubulin folding cofactor A is a member of the TBCA family. It is crucial for cell viability, if reduced it causes a decrease in the amount of soluble tubulin, alterations in microtubules and G1 cell cycle arrest. The product of tubulin folding cofactor A gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.

References

Strausberg RL. et al., 2002, Proc Natl Acad Sci. 99(26):16899-903.
Irwin DM. et al., 2003, J Mol Evol. 56 (2): 234-42.
Sklar P. et al., 2011, Nat Genet. 43 (10): 977-83.