PARVA / Actopaxin Protein (GST Tag)

27.11.2012

Sino Biological Inc. liefert PARVA / Actopaxin Protein (GST Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über PARVA / Actopaxin Protein (GST Tag) lesen Sie bitte: http://www.sinobiological.com/PARVA-Actopaxin-Protein-g-9916.html

Produkt-Information von PARVA / Actopaxin Protein

Synonym	PARVA, MXRA2
Protein Construction	A DNA sequence encoding the mature form of human PARVA(Q9NVD7-1) (Met1-Glu372) was fused with the GST tag at the N-terminus.
Source	Human
Expression Host	E.coli

QC Testing von PARVA / Actopaxin Protein

Purity	> 60 % as determined by SDS-PAGE	SDS-PAGE: PARVA protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant human PARVA /GST chimera consists of 606 amino acids and has a predicted molecular mass of 69.4 kDa. It migrates as an approximately 69 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von PARVA / Actopaxin Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von PARVA / Actopaxin Protein

Actopaxin, also known as alpha-parvin, is a member of the parvin family. It contains 2 CH (calponin-homology) domains and is widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. It interacts with integrin-linked protein kinase and probably with actin and the LD1 and LD4 motifs of PXN. Actopaxin probably plays a role in the regulation of cell adhesion and cytoskeleton organization. Actopaxin binds directly to both F-actin and paxillin LD1 and LD4 motifs. Actopaxin binds directly to both F-actin and paxillin LD1 and LD4 motifs. Actopaxin also exhibits robust focal adhesion localization in several cultured cell types but is not found along the length of the associated actin-rich stress fibers. It is absent from actin-rich cell-cell adherens junctions.

References

Korenbaum E. et al., 2002, Gene. 279 (1): 69-79.
Nikolopoulos SN. et al., 2002, J Biol Chem. 277 (2): 1568-75.
Tu Y. et al., 2001, J Cell Biol. 153 (3): 585-98.