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Sino Biological Inc. liefert SerpinA6 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.
Weitere Informationen über SerpinA6 Antikörper lesen Sie bitte: http://www.sinobiological.com/SerpinA6-Antibody-g-10125.html
| Immunogen | Recombinant Human SerpinA6 protein (Catalog#10998-H08H) |
| Antibody Type | Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform ) |
| Clone ID | 037 |
| Ig Type | Rabbit IgG |
| Formulation | 0.2 μm filtered solution in PBS with 5% trehalose |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human SerpinA6 (rh SerpinA6; Catalog#10998-H08H; NP_001747.2; Met 1-Val 405). |
| Specificity | Human SerpinA6 |
| Direct ELISA | This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human SerpinA6. The detection limit for Human SerpinA6 is approximately 0.00975 ng/well. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. |
Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Serpin Superfamily>>SerpinA6
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| SerpinA6 | Human | SerpinA6 Protein, Recombinant | 10998-H08H |
| SerpinA6 | Mouse | SerpinA6 Protein, Recombinant | 50314-M08H |
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human SerpinA6 | WB, ELISA | SerpinA6 Antibody, Rabbit PAb | 10998-RP02 |
| Human SerpinA6 | ELISA | SerpinA6 Antibody | 10998-R037 |
| Mouse SerpinA6 | WB, ELISA | SerpinA6 Antibody, Rabbit PAb | 50314-RP02 |
The serpin peptidase inhibitor, clade A, member 6 (SerpinA6), also known as corticosteroid-binding globulin or CBG, is a member of Serpin (Serine Protease Inhibitors) superfamily. The superfamily of serine protease inhibitors (SERPINs) plays a key role in controlling the activity of proteinases in diverse biological processes. SerpinA6 is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and SerpinA6, and promotes a significant and local release of glucocorticoids (over 90% of them are bound to SerpinA6 in human plasma). In this context, SerpinA6 directs glucocorticoids to sites of inflammation, and plays in consequence a crucial role in efficient glucocorticoid action in physiology. As a specific high-affinity plasma transport glycoprotein for cortisol. Stress-induced falls in CBG levels may heighten hypothalamic-pituitary-adrenal axis responses and CBG. The tissue interactions may allow targeted cortisol delivery. Three genetic variants of CBG have been identified that reduce cortisol binding affinity and/or CBG levels. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. SerpinA6/CBG is the major transport protein for glucocorticoids and progestins in the blood of most vertebrates, and may involved in obesity and stress sensitivity.
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