Layilin Antikörper

09.11.2012

Sino Biological Inc. liefert Layilin Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Layilin Antikörper lesen Sie bitte: http://www.sinobiological.com/Layilin-Antibody-g-10133.html

Produkt-Information von Layilin Antikörper

Immunogen	Recombinant Mouse Layilin protein (Catalog#10208-H08H)
Antibody Type	Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
Clone ID	007
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Layilin (rM Layilin; Catalog#10208-H08H; NP_849156.1; Met 1-Glu 220).

Usage Guide von Layilin Antikörper

Specificity	Mouse Layilin
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human Layilin. The detection limit for Human Layilin is approximately 0.00975 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von Layilin Antikörper

Related Areas:

Cancer>>Angiogenesis>>ECM Molecules in Angiogenesis>>Layilin

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Hyaluronic Acid Binding Protein>>Layilin

Immunology>>Adhesion Molecule>>Lectin>>Layilin

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Layilin	Human	Layilin/Fc Protein, Recombinant	10208-H02H
Layilin	Human	Layilin Protein, Recombinant	10208-H08H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human Layilin	WB	Mouse Monoclonal Antibody	10208-MM01
Human Layilin	ELISA	Mouse Monoclonal Antibody	10208-MM02
Human Layilin	WB, ELISA	Rabbit Polyclonal Antibody	10208-RP01
Human Layilin	WB, ELISA	Layilin Antibody (Antigen Affinity Purified)	10208-RP02
Human Layilin	ELISA	Layilin Antibody	10208-R007

Hintergrund von Layilin Antikörper

Layilin (LAYN), a recently characterized transmembrane protein with homology to C-type lectins, is present in numerous cell lines and tissue extracts. As one of the adaptor proteins, talin mediates the interactions between the actin filaments and the cell membrane by binding to integral membrane proteins and to the cytoskeleton. Layilin is a newly identified membrane-binding site for talin in peripheral ruffles of spreading cells, and its adjacent LH2-LH3 tandem arrays in the cytoplasmic domain provide docking sites for talin. Layilin binds specifically to hyaluronan (HA) through its extracellular domain, a ubiquitous extracellular matrix component in most animal tissues and body fluids, but not to other tested glycosaminoglycans. All the above actions reveal an interesting parallel between layilin and the known HA receptor CD44. In addition, merlin and radixin have been identified as different intracellular binding partners of layilin. Accordingly, it has been suggested that layilin plays roles in a variety of cellular processes, including cell shape, adhesion, motility, and homeostasis, as well as signal transduction.

References

Borowsky, M.L. et al., 1998, J. Cell Biol. 143: 429-442.
Bono, P. et al., 2001, Mol. Biol. Cell. 12: 891-900.
Rees, D.J.G. et al., 1990, Nature. 347: 685-689.
Bono, P. et al., 2005, Exp.Cell. Res. 308: 177-187.
Schoenwaelder, S.M. et al., 1999, Curr Opin Cell Biol. 11: 274-286.