TRAIL R2 / TNFRSF10B / CD262 Antikörper

09.11.2012

Sino Biological Inc. liefert TRAIL R2 / TNFRSF10B / CD262 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über TRAIL R2 / TNFRSF10B / CD262 Antikörper lesen Sie bitte: http://www.sinobiological.com/TRAIL-R2-TNFRSF10B-CD262-Antibody-g-10121.html

Produkt-Information von TRAIL R2 / TNFRSF10B / CD262 Antikörper

Immunogen	Recombinant Mouse TRAIL R2 / TNFRSF10B / CD262 protein (Catalog#50412-M08H)
Antibody Type	Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
Clone ID	131
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	This antibody was obtained from a rabbit immunized with purified, recombinant Mouse TRAIL R2 / TNFRSF10B / CD262 (rM TRAIL R2 / TNFRSF10B / CD262; Catalog#50412-M08H; NP_064671.2; Met 1-Ser 177).

Usage Guide von TRAIL R2 / TNFRSF10B / CD262 Antikörper

Specificity	Mouse TRAIL R2 / TNFRSF10B / CD262
	No cross-reactivity in ELISA with Human TNFRSF10B
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse TNFRSF10B. The detection limit for Mouse TNFRSF10B is approximately 0.00245 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von TRAIL R2 / TNFRSF10B / CD262 Antikörper

Related Areas:

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>TRAIL R2/TNFRSF10B/CD262

Immunology>>Cytokine & Receptor>>TNF Superfamily>>TRAIL R2/TNFRSF10B/CD262

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>TRAIL R2/TNFRSF10B/CD262

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
TRAIL R2/TNFRSF10B/CD262	Human	TRAIL R2/TNFRSF10B/CD262/Fc Protein, Recombinant	10465-H03H
TRAIL R2/TNFRSF10B/CD262	Human	TRAIL R2/TNFRSF10B/CD262 Protein, Recombinant	10465-H08H
TRAIL R2/TNFRSF10B/CD262	Mouse	TRAIL R2/TNFRSF10B/CD262/Fc Protein, Recombinant	50412-M03H
TRAIL R2/TNFRSF10B/CD262	Mouse	TRAIL R2/TNFRSF10B/CD262 Protein, Recombinant	50412-M08H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human TRAIL R2/TNFRSF10B/CD262	WB, ELISA	TRAIL R2/TNFRSF10B/CD262 Antibody, Rabbit MAb	10465-R102
Human TRAIL R2/TNFRSF10B/CD262	WB, FCM	TRAIL R2 / TNFRSF10B / CD262 Antibody ( PE )	10465-R102-P
Human TRAIL R2/TNFRSF10B/CD262	WB, ELISA	Rabbit Polyclonal Antibody	10465-RP01
Human TRAIL R2/TNFRSF10B/CD262	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10465-RP02
Mouse TRAIL R2/TNFRSF10B/CD262	WB, ELISA	TRAIL R2/TNFRSF10B/CD262 Antibody, Rabbit PAb	50412-RP01
Mouse TRAIL R2/TNFRSF10B/CD262	WB, ELISA	TRAIL R2/TNFRSF10B/CD262 Antibody, Rabbit PAb (Antigen Affinity Purified)	50412-RP02
Mouse TRAIL R2/TNFRSF10B/CD262	ELISA	TRAIL R2 / TNFRSF10B / CD262 Antibody	50412-R131

Hintergrund von TRAIL R2 / TNFRSF10B / CD262 Antikörper

TRAILR2, also known as DR5 and TNFRSF10B, is the fifth death domain-containing member of the TNFR family and a receptor for TRAIL/TNFSF10. TRAILR2 is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. This single-pass transmembrane protein contains two cysteine-rich repeat units in its extracellular region, followed by a predicted hydrophobic transmembrane segment and a 209 aa long cytoplasmic tail containing a typical "death domain". Upon ligand binding, the adapter molecule FADD recruits caspase-8 to the activated receptor TNFRSF10B. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. TRAIL-R2 exhibits high structural and functional homology to TRAIL-R1 (DR-4), and TNFRSF10B expression is regulated by the tumor suppressor p53. Further, it is also indicated that the activation of NF-kappa-B can be promoted by TNFRSF10B.

References

Henning Walczak, et al., 1997, The EMBO Journal.16, No.17: 5386-5397.
G. Pan, et al.,1997, Science, 277: 815-818.
Pascal Schneider, et al., 1997, FEBS Letters, Volume 416, Issue 3: 329-334.
Gavin R.Screaton, et al., 1997, Current Biology, Volume 7, Issue 9: 693-696.
Sarah G Hymowit, et al., 1999, Molecular Cell, Volume 4, Issue 4: 563-5.
Preet M. Chaudhary, et al., 1997, Immunity, Volume 7, Issue 6: 821-830.