SCN3B Protein (His Tag)

17.10.2012

Produkt-Information von SCN3B Protein

Synonym	SCN3B, KIAA1158
Protein Construction	A DNA sequence encoding the mature form of human SCN3B (Q9NY72) extracellular domain (Met1-Glu159) was expressed with a polyhistidine tag at the C-terminus.
Source	Human
Expression Host	Human Cells

QC Testing von SCN3B Protein

Purity	> 95% as determined by SDS-PAGE	SDS-PAGE: SCN3B protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Phe 23
Molecular Mass	The recombinant human SCN3B consists of 148 amino acids and predicts a molecular mass of 17.2 KDa. It migrates as an approximately 29 and 34 kDa due to different glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von SCN3B Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von SCN3B Protein

SCN3B (sodium channel, voltage-gated, type III, beta ,human IgG1-Fc chimera) belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family. It contains 1 Ig-like C2-type (immunoglobulin-like) domain. SCN3B modulates channel gating kinetics; causes unique persistent sodium currents; inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. Defects in SCN3B are the cause of Brugada syndrome type 7. A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram. It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.

References

Morgan K. et al., 2000, Proc Natl Acad Sci. 97 (5): 2308-13.
Hartley JL. et al. Genome Res. 10 (11): 1788-95.
Hirosawa M. et al., 2000, DNA Res. 6 (5): 329-36.

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Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
SCN3B	Human	SCN3B Protein, Recombinant	13500-H02H
SCN3B	Human	SCN3B Protein, Recombinant	13500-H08H