S100P Antikörper (Antigen Affinität reinigt)

13.03.2012

Produkt-Information von S100P Antikörper

Immunogen	Recombinant Human S100P protein (Catalog#12635-HNAE)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Human S100P (rh S100P;Catalog#12635-HNAE; P25815; Met 1-Lys 95). S100P specific IgG was purified by Human S100P affinity chromatography.

S100P Antikörper Usage Guide

Specificity	Human S100P
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human S100P in WB. Using a DAB detection system, the detection limit for Human S100P is approximately 1 ng/lane under non-reducing conditions and 4 ng/lane under reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human S100P. The detection limit for Human S100P is approximately 0.00975 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von S100P Antikörper

Protein S100-P, also known as Protein S100-E, S100 calcium-binding protein P, S100P and S100E, is a nucleus and cytoplasm protein which belongs to theS-100 family. S100P / S100E contains twoEF-hand domains. S100P protein regulates calcium signal transduction and mediates cytoskeletal interaction, protein phosphorylation and transcriptional control. S100P / S100E overexpression can upregulate androgen receptor expression and thereby promote prostate cancer progression by increasing cell growth. S100P / S100E may directly confer resistance to chemotherapy. S100P / S100E induction may be considered an important step in the initial stage of lung adenocarcinomas, whereas its downregulation in advanced stages seems to be important for tumour progression in which DNA methylation and/or feedback transcription processes play a critical role. S100P / S100E plays a major role in the aggressiveness of pancreatic cancer that is likely mediated by its ability to activate RAGE. Interference with S100P / S100E may provide a novel approach for treatment of pancreatic cancer. S100P / S100E could be considered a potential drug target or a chemosensitization target, and could also serve as a biomarker for aggressive, hormone-refractory and metastatic prostate cancer.

References

Arumugam,T. et al., 2005, Clin Cancer Res. 11 (15): 5356-64.
Basu,G.D. et al., 2008, Int J Cancer. 123 (2): 330-9.
Rehbein,G. et al.,2008, Int J Mol Med. 22 (1): 69-77.
Heil,A. et al., 2011, J Biol Chem. 286 (9): 7227-38.

Sino Biological Inc. liefert S100P Antikörper (Antigen Affinität reinigt) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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