TNF-beta / TNFSF1 / Lymphotoxin alpha Antikörper (Antigen Affinität reinigt)

13.03.2012

Produkt-Information von TNF-beta / TNFSF1 / Lymphotoxin alpha Antikörkper

Immunogen	Recombinant Human TNF-beta / TNFSF1 / Lymphotoxin alpha protein (Catalog#10270-HNAE)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Human TNF-beta / TNFSF1 / Lymphotoxin alpha (rh TNF-beta / TNFSF1 / Lymphotoxin alpha; Catalog#10270-HNAE; P01374; Leu 35-Leu 205). TNF-beta / TNFSF1 / Lymphotoxin alpha specific IgG was purified by Human TNF-beta / TNFSF1 / Lymphotoxin alpha affinity chromatography.

TNF-beta / TNFSF1 / Lymphotoxin alpha AntikörperUsage Guide

Specificity	Human TNF-beta / TNFSF1 / Lymphotoxin alpha
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human TNF-beta in WB. Using a DAB detection system, the detection limit for Human TNF-beta is approximately 0.5 ng/lane under non-reducing conditions and reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human TNF-beta. The detection limit for Human TNF-beta is approximately 0.039 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von TNF-beta / TNFSF1 / Lymphotoxin alpha Antikörper

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Hintergrund von TNF-beta / TNFSF1 / Lymphotoxin alpha Antikörper

Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1 and TNFB, is a secreted protein which belongs to thetumor necrosis factor family. TNFB / TNF-beta / LTA is a highly inducible, secreted, and exists as homotrimeric molecule. It is a cytokine that in its homotrimeric form binds to TNFRSF1A / TNFR1, TNFRSF1B / TNFBR and TNFRSF14 / HVEM. In its heterotrimeric form with LTB, TNFB / TNF-beta / LTA binds to TNFRSF3 / LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells. TNFB / TNF-beta / LTA forms heterotrimers with lymphotoxin-betawhich anchors lymphotoxin-alpha to the cell surface. It mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. TNFB / TNF-beta / LTA is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in TNFB / TNF-beta / LTA are a cause of susceptibility psoriatic arthritis which is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy.

References

Browning, J L; et al.,1995,J. Immunol. 154 (1): 33-46.
Williams-Abbott, L; et al.,1997, J. Biol. Chem. 272 (31): 19451-6.
Browning, J L; et al.,1997, J. Immunol. 159 (7): 3288-98.
Balding J., et al., 2003, Arthritis Rheum. 48: 1408-13.
Alcaies A., et al., 2007, Nat. Genet. 39: 517-22.

Sino Biological Inc. liefert TNF-beta / TNFSF1 / Lymphotoxin alpha Antikörper (Antigen Affinität reinigt) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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