Rat TNFSF15 / TL1A Protein

28.11.2012

Sino Biological Inc. liefert Rat TNFSF15 / TL1A Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat TNFSF15 / TL1A Protein lesen Sie bitte: http://www.sinobiological.com/TNFSF15-TL1A-Protein-g-9923.html

Produkt-Information von TNFSF15 / TL1A Protein

Synonym	TNFSF15, Tl1, Vegi
Protein Construction	A DNA sequence encoding the rat TNFSF15 (Q8K3Y7)(Asp94-Ile252) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Source	Rat
Expression Host	Human Cells

QC Testing von TNFSF15 / TL1A Protein

Purity	> 90% as determined by SDS-PAGE	SDS-PAGE: TL1A protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Asp 94
Molecular Mass	The recombinant rat TNFSF15/Fc is a disulfide-linked homodimer. The reduced monomer comprises 419 amino acids and has a predicted molecular mass of 46.5 kDa. The apparent molecular mass of the protein is approximately 55 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von TNFSF15 / TL1A Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von TNFSF15 / TL1A Protein

TL1A, also known as TNFSF15, is a member of the tumor necrosis factor (TNF) ligand family. It is a cytokine that specifically expressed in endothelial cells. TL1A also can be detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. TL1A is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor.

References

Jin T. et al., 2007, Biochem Biophys Res Commun. 364 (1): 1-6.
Cassatella MA. et al., 2007, J Immunol. 178 (11): 7325-33.
Prehn JL. et al., 2007, J Immunol. 178 (7): 4033-8.