Mouse FLT3L / Flt3 ligand Protein

28.11.2012

Sino Biological Inc. liefert Mouse FLT3L / Flt3 ligand Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Mouse FLT3L / Flt3 ligand Protein lesen Sie bitte: http://www.sinobiological.com/FLT3L-Flt3 ligand-Protein-g-9922.html

Produkt-Information von FLT3L / Flt3 ligand Protein

Synonym	FLT3L, Flt3l
Protein Construction	A DNA sequence encoding the mouse FLT3L (P49772-1) (Met1- Arg188 ) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Source	Mouse
Expression Host	Human Cells

QC Testing von FLT3L / Flt3 ligand Protein

Purity	> (65.8+26.5) % as determined by SDS-PAGE	SDS-PAGE: FLT3L protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gly 27
Molecular Mass	The recombinant mouse FLT3L /Fc is a disulfide-linked homodimer. The reduced monomer comprises 403 amino acids and has a predicted molecular mass of 45.4 kDa. The apparent molecular mass of the protein is approximately 56 and 35 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von FLT3L / Flt3 ligand Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von FLT3L / Flt3 ligand Protein

FLT3L, also known as flt3 ligand, acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. It is a small molecule which also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells. Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3L is crucial for steady-state pDC and cDC development. It controls the development of DCs and is particularly important for plasmacytoid DCs and CD8-positive classical DCs and their CD103-positive tissue counterparts.

References

Hannum C. et al., 1994, Nature. 368 (6472): 643-8.
Lyman SD. et al., 1995, Oncogene. 10 (1): 149-57.
Lyman SD. et al., 1994, Cell. 75 (6): 1157-67.