Rat TNFRSF17 Protein

Produkt-Information von TNFRSF17 Protein

TNFRSF17 Protein QC Testing

Purity	>99 % as determined by SDS-PAGE	SDS-PAGE: TNFRSF17 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu
Molecular Mass	The recombinant Rat TNFRSF17/Fc is a disulfide-linked homodimer. The reduced monomer comprises 309 amino acids and has a predicted molecular mass of 34 kDa. The apparent molecular mass of the protein is approximately 40 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von TNFRSF17 Protein

Verwandte Produkte & Themen von TNFRSF17 Protein

Immunology>>Cytokine & Receptor>>TNF Superfamily>>TNFRSF17/BCMA

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>TNFRSF17/BCMA/CD269

Beschreibung von TNFRSF17 Protein

The tumor necrosis factor (TNF) receptor superfamily are a group of cell surface receptors critically involved in the maintenance of homeostasis of the immune system. By interacting with their corresponding ligands, these receptors either induce cell death or promote cell survival of immune cells. Human tumor necrosis factor receptor superfamily member 17, also known as B-cell maturation protein, TNFRSF17, BCMA, and CD269, is a single-pass type I II membrane protein which contains one TNFR-Cys repeat. TNFRSF17 is a member of the TNF receptor superfamily, and is preferentially expressed in mature B lymphocytes. It binds specifically to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), as well as various TNFR-associated factor (TRAF) family members including TRAF1, TRAF2 and TRAF3 adaptor proteins, and thus transduces signals for cell survival and proliferation. Lacking a "death domain", overexpression of TNFRSF17 activates NF-kappa B and c-Jun N-terminal kinase. TNFRSF17 is also found in a perinulear Golgi-like structure.

References

1. Hatzoglou A. et al., 2000, J Immunol. 165 (3): 1322-1330.
2. Zhou T. et al., 2002, Immunol Res. 26 (1-3): 323-336.
3. Liu Y. et al., 2003, Nature. 423: 49-56.
4. Hymowitz SG. et al., 2005, J Biol Chem. 280: 7218-7227.

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