IL4R / Il4ra Protein

Produkt-Information von IL4R / Il4ra Protein

QC Testing von IL4R / Il4ra Protein

Purity	>90% as determined by SDS-PAGE	SDS-PAGE: IL4R / Il4ra protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ile 26
Molecular Mass	The recombinant rat IL4R  is a disulfide-linked homodimer. The reduced monomer comprises 218 amino acids and predicts a molecular mass of 25.3 kDa. The apparent molecular mass of  the recombinant protein is approximately 46 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IL4R / Il4ra Protein

Verwandte Produkte & Themen von IL4R / Il4ra Protein

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-4R/CD124

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>IL-4R/CD124

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>> IL-4R/CD124

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>IL-4R/CD124

Beschreibung von IL4R / Il4ra Protein

IL-4 is a pleiotropic cytokine produced by activated Th2 cells and mast cells, and plays a pivotal role in immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. Hematopoietic cellular responses to IL-4 are mediated by a high affinity receptor complex comprised of the 140 kDa IL4Rα (CD124)subunit and the 70 kDa common cytokine γc chain (CD132). In non-hematopoietic cells, the IL4Rα subunit associates with the IL13Rα chain and also serves as a functional complex for IL-13. IL4Rα is a single-pass type I  transmembrane protein containing ser/Pro-rich regions in cytoplasmic domain similar to those present in the IL-2 receptor and GM-CSF receptor ß-chains. As a receptor for both IL4 and IL13, IL4Rα couples to the JAK1/2/3-STAT6 pathway, and is involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammmation, as well as promoting differentiation of Th2 cells. Two transcript variants encoding different isoforms of IL4Rα, a membrane-bound and a soluble form, have been found, and the soluble form of IL4Rα can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells.

References

1. Grabstein K. et al.,1986, J Exp Med. 163: 1405-14.
2. Yokota T. et al., 1988, Immunol Rev. 102: 137-87.
3. Kotowicz K. et al., 1996, Int Immunol. 8: 1915-25.
4. Murata T. et al., 1998, Int J Mol Med. 1: 551-7.
5. Nelms K. et al., 1999, Ann Rev Immunol. 17: 701-38.
6. Hackstein H. et al.,1999, Tissue Antigens. 54 (5): 471-7.
7. Gessner A. et al., 2000, Immunobiology. 201 (3-4): 285-307.

Sino Biological Inc. liefert Rat IL4R / Il4ra Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat IL4R / Il4ra Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/TNFRSF17-Protein-g-9296.html