Rat TIMP-1 / TIMP1 Protein (Naitve)

Produkt-Information von TIMP-1 / TIMP1 Protein

QC Testing von TIMP-1 / TIMP1 Protein

Purity	> 97 % as determined by SDS-PAGE	SDS-PAGE: TIMP-1 / TIMP1 protein
Bio-activity	Measured by its ability to inhibit human MMP2 cleavage of a fluorogenic peptide substrate MCA-PLGLDPA-AR-NH2, AnaSpec Catalog # 27076. The IC50 value is approximately 4 nM.
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Cys 24
Molecular Mass	The recombinant rat TIMP1 consists of 194 amino acids and has a predicted molecular mass of 21.5 kDa. As a result of glycosylation, the apparent molecular mass of  the recombinant protein is approximately 28 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of 50mMTris,100mMNaCl, PH7. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von TIMP-1 / TIMP1 Protein

Verwandte Produkte & Themen von TIMP-1 / TIMP1 Protein

Enzyme>>Protease & Regulator>>Metalloprotease & Regulator>>Tissue Inhibitor of Metalloproteinase>>TIMP-1/TIMP1

Cancer>>Angiogenesis>>Tissue Inhibitor of Metalloproteinase>>TIMP-1/TIMP1

Cancer>>Cancer Biomarkers>>TIMP-1/TIMP1

Beschreibung von TIMP-1 / TIMP1 Protein

Tissue inhibitors of metalloproteinases (TIMP) family are natural inhibitors of the matrix metalloproteinases (MMPs), the zinc enzymes involved in extracellular matrix maintenance and remodeling. The TIMP family encompasses four members (TIMP1-4), and the inducible form TIMP-1/TIMP1 is a 28 kDa glycoprotein expressed by a variety of cell types. It inhibits most MMPs except membrane-type MMP subfamily by forming non-covalent binary complex, but also interacts with the hemopexin-like (PEX) domain of pro MMP-9. TIMP-1/TIMP1 has been identified as a multifunctional molecule with divergent functions. It exhibits keratinocyte and fibroblast growth factor-like activity and acts as a cell survival factor, and additionally participates in tumor metastasis, angiogenesis, inflammatory responses, as well as CNS homeostasis. Thus, TIMP-1/TIMP1 overexpression may serve to help identify patients with particularly aggressive disease for adjuvant treatments.

References

1. Osthues A. et al., 1992, FEBS Lett. 296: 16-20.
2. Aljada IS. et al., 2004, J Clin Oncol. 16: 3218-29.
3. Hornebeck W. 2004, Pathol Biol. 51: 569-573.
4. Gardner J. et al., 2003, J Neurosci Res. 74: 801-6.

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