Rat GDNF Protein (His Tag)

Produkt-Information von GDNF Protein

QC Testing von GDNF Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: GDNF protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant rat GDNF consists of  150 amino acids and predicts a molecular mass of 17.1 KDa. It migrates as an approximately 20 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of 20mM Tris, 500mM NaCl, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von GDNF Protein

Verwandte Produkte & Themen von GDNF Protein

Stem Cell>>Neural Stem Cell (NSC)>>Neural Crest Stem Cell>>Neural Crest Effector>> GDNF

Beschreibung von GDNF Protein

Glial cell derived neurotrophic factor (GDNF) belongs to the GDNF family of ligands(GFL). It is a founding member of GFL. GFL comprises four neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF), neurturin (NRTN), artemin (ARTN), and persephin (PSPN) and plays a role in a number of biological processes including cell survival, neurite outgrowth, cell differentiation and cell migration. GDNF is a highly conserved neurotrophic factor. It plays a key role in the promotion of the survival of dopaminergic neurons. The recombinant form of this protein promotes the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. GDNF also regulates kidney development and spermatogenesis, and it affects alcohol consumption. GDNF has been taken as a potent survival factor for central motoneurons and it can cause two Parkinson's disease clinical trial and a number of animal trials. GDNF may be a new target for drug addiction and alcoholism treatment.

References

1. Oppenheim RW. et al., 1995, Nature. 373 (6512): 344-6.
2. Tomac A. et al., 1995, Nature. 373 (6512): 335-9.
3. Schindelhauer D. et al., 1996, Genomics. 28 (3): 605-7.
4. Carnicella S. et al., 2008, Proc Natl Acad Sci. 105 (23): 8114-9.

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