Rat SDC1 / Syndecan-1 / SYND1 Protein

Sino Biological Inc. liefert Rat SDC1 / Syndecan-1 / SYND1 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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Produkt-Information von SDC1 / Syndecan-1 / SYND1 Protein

QC Testing von SDC1 / Syndecan-1 / SYND1 Protein

Purity	> 90% as determined by SDS-PAGE	SDS-PAGE: SDC1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gln 23
Molecular Mass	The recombinant rat SDC1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 472 amino acids and has a predicted molecular mass of 51.2 kDa. The apparent molecular mass of the protein is approximately 92 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von SDC1 / Syndecan-1 / SYND1 Protein

Verwandte Produkte & Themen von SDC1 / Syndecan-1 / SYND1 Protein

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Proteoglycan>>Syndecan-1/SDC1/CD138

Immunology>>Cluster of Differentiation>>Syndecan-1/SDC1/CD138

Beschreibung von SDC1 / Syndecan-1 / SYND1 Protein

Syndecan-1, also known as SYND1, CD138 and SDC1, is a single-pass type I  membrane protein which belongs to the syndecan proteoglycan family. CD138 / Syndecan-1 is well known to be associated with cell proliferation, adhesion, and migration in various types of malignancies. It is a cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. CD138 / Syndecan-1 is a cell-surface heparan sulfate proteoglycan expressed on most epithelial cells, and decreased CD138 expression is associated with increased invasive and metastatic potential in carcinomas. Within the hematopoietic system, CD138 is an excellent marker of plasmacytic differentiation. CD138 / Syndecan-1 is a cell surface proteoglycan that binds cells to the extracellular matrix and its expression is down-regulated in many cellular transformation models. CD138 / Syndecan-1 is a new simple non-invasive marker for predicting liver fibrosis in patients with chronic hepatitis C. The relevance of this marker in combination with other fibrosis markers should be explored. CD138 / Syndecan-1 might contribute to urothelial carcinoma cell survival and progression. It could be a new therapeutic target in urinary bladder cancer.

References

1. O'Connell FP. et al., 2004, Am J Clin Pathol. 121 (2):254-63.
2. Gkden N. et al., 2006, Appl Immunohistochem Mol Morphol. 14 (2): 173-7.
3. Sun WP. et al., 2007,Cell Mol Immunol. 4 (3): 209-14.
4. Zvibel I. et al., 2009, Liver Int. 29 (2): 208-12.
5. Shimada K. et al., 2010, Cancer Sci. 101 (1): 155-60.