Rat LGALS1 / Galectin-1 Protein (Native)

Sino Biological Inc. liefert Rat LGALS1 / Galectin-1 Protein (Native) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat LGALS1 / Galectin-1 Protein (Native) lesen Sie bitte: http://www.sinobiological.com/LGALS1-Galectin-1-Protein-g-10002.html

Produkt-Information von LGALS1 / Galectin-1 Protein

QC Testing von LGALS1 / Galectin-1 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: LGALS1 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ala 2
Molecular Mass	The recombinant rat Galectin1 consists of 135 amino acids and has a predicted molecular mass of 14.9 kDa. As a result of glycosylation, the apparent molecular mass of  the recombinant protein is approximately 16 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.5. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von LGALS1 / Galectin-1 Protein

Verwandte Produkte & Themen von LGALS1 / Galectin-1 Protein

Cardiovascular>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>Galectin-1

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>Galectin-1

Immunology>>Adhesion Molecule>>Lectin>> Galectin-1

Beschreibung von LGALS1 / Galectin-1 Protein

Galectin-1 (Gal-1, GAL1), the first identified member of the β-galactoside-binding animal lectin family, and exists as a homodimer of a single carbohydrate-recognition domain. Galectin-1 is expressed in a variety of cell types, including thymic epithelial cells, endothelial cells, dendritic cells, macrophages, fibroblasts, and bone marrow stromal cells. There is increased galectin-1 expression in many types of cancer, including colon, breast, ovary and prostate carcinomas. Several potential glycoprotein ligands for galectin-1 have been identified, including lysosome-associated membrane glycoproteins and fibronectin, laminin, as well as T-cell glycoproteins CD43 and CD45. It is revealed that Galectin-1 can induce apoptosis of activated human T cells and human T leukaemia cell lines, while resting T cells also bound galectin-1, but did not undergo apoptosis. Galectin-1 modulates inflammatory responses and contributes to tumor progression and immune cell homeostasis. Galectin-1 regulates the inflammatory responses of neutrophils, mast cells, and macrophages and also associates with components of the complement system. Galectin-1 is thus suggested to act as an autocrine negative regulatory “cytokine,” killing T cells to terminate an immune response.

References

1. Nozomu Nishi. et al., 2008, Glycobiology. 18 (12): 1065-73.
2. Jiale He. et al., 2004, The Journal of Biological Chemistry. 279 (6): 4705-12.
3. Santiago Di Lella. et al., 2009, Biochemistry. 48 (4): 786-91.
4. Nicola TINARI1. et al., 2001, Int J Cancer: 91: 167-72.
5. Magali Fouillit. et al., 2000, Glycobiology. 10 (4): 413-9.