Rat PDGFRB / PDGFR-1 Protein (His Tag)

Sino Biological Inc. liefert Rat PDGFRB / PDGFR-1 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat PDGFRB / PDGFR-1 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/PDGFRB-PDGFR-1-Protein-g-10011.html

Produkt-Information von PDGFRB / PDGFR-1 Protein

QC Testing von PDGFRB / PDGFR-1 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: PDGFRB protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Leu 32
Molecular Mass	The recombinant rat PDGFRB comprises 510 amino acids and predicts a molecular mass of 57.6 kDa. The apparent molecular mass of  the recombinant protein is approximately 92 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von PDGFRB / PDGFR-1 Protein

Verwandte Produkte & Themen von PDGFRB / PDGFR-1 Protein

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>PDGFRB/CD140b

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>PDGFRB/CD140b

Cancer>>Cancer Stem Cell (CSC)>>PDGFRB/CD140b

Cancer>>Cancer Biomarkers>>PDGFRB/CD140b

Cancer >>Growth factor & Receptor>>PDGF & Receptor>>PDGFRB/CD140b

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>PDGFRB/CD140b

Immunology>>Cluster of Differentiation>>Other>>PDGFRB/CD140b

Beschreibung von PDGFRB / PDGFR-1 Protein

Beta-type platelet-derived growth factor receptor, also known as CD140b, PDGFRB, PDGF-R-beta, PDGF receptor-β, is a member of the protein kinase superfamily and CSF-1/PDGF receptor subfamily. The PDGF family consists of PDGF-A, -B, -C and -D, which form either homo- or heterodimers (PDGF-AA, -AB, -BB, -CC, -DD). The four PDGFs are inactive in their monomeric forms. The PDGFs bind to the protein tyrosine kinase receptors PDGF receptor-α and -β. These two receptor isoforms dimerize upon binding the PDGF dimer, leading to three possible receptor combinations, namely -αα, -ββ and -αβ. The extracellular region of the PDGF receptor-β consists of five immunoglobulin-like domains while the intracellular part is a tyrosine kinase domain. The ligand-binding sites of PDGF receptor-α and -β are located to the three first immunoglobulin-like domains. PDGF-CC specifically interacts with PDGFR-αα and -αβ, but not with –ββ, and thereby resembles PDGF-AB. PDGF-DD binds to PDGFR-ββ with high affinity, and to PDGFR-αβ to a much lower extent and is regarded as PDGFR-ββ specific. PDGF-AA binds only to PDGFR-αα, while PDGF-BB is the only PDGF that can bind all three receptor combinations with high affinity.

References

1. Chi, KD. et al., 1997, Oncogene 15: 1051-7.
2. Arcaro, A. et al., 2000, Mol. Cell. Biol. 20: 3817-30.
3. Bergsten, E. et al., 2001, Nat. Cell Biol. 3: 512-16.
4. Zhang, Z. et al., 2004, Protein Sci. 13: 2819-24.
5. Morerio, C. et al., 2004, Cancer Res. 64: 2649-51.