Rat PVRL1 / HVEC / Nectin-1 Protein (His Tag)

Produkt-Information von PVRL1 / HVEC / Nectin-1 Protein

QC Testing von PVRL1 / HVEC / Nectin-1 Protein

Purity	> 97 % as determined by SDS-PAGE	SDS-PAGE: PVRL1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gln 31
Molecular Mass	The recombinant rat PVRL1 comprises 335 amino acids and predicts a molecular mass of 37.6 kDa. The apparent molecular mass of  the recombinant protein is approximately 55-60 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von PVRL1 / HVEC / Nectin-1 Protein

Verwandte Produkte & Themen von PVRL1 / HVEC / Nectin-1 Protein

Neuroscience>>Synaptic Protein>>CD111/Nectin-1/PVRL1

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>CD111/Nectin-1/PVRL1

Immunology>>Cluster of Differentiation>>CD111/Nectin-1/PVRL1

Beschreibung von PVRL1 / HVEC / Nectin-1 Protein

Poliovirus receptor-related protein 1, also known as Herpes virus entry mediator C, Nectin-1, Herpesvirus Ig-like receptor, CD111, PVRL1 and HVEC, is a single-pass type I  membrane protein which belongs to the nectin family. PVRL1 acts in the initiation and maintenance of epithelial adherens junctions. Both rare and common mutations within PVRL1 make a minor contribution to disrupting the initiation and regulation of cell-to-cell adhesion and downstream morphogenesis of the embryonic face. PVRL1 can form trans-heterodimers with PVRL3 / nectin-3 and with PVRL4 / nectin-4. PVRL1 interacts (via C-terminus) with afadin (via PDZ domain). This interaction recruits PVRL1 to cadherin-based adherens junctions. PVRL1 interacts with integrin alphaV / beta3. It also interacts with herpes simplex virus 1 (HHV-1), herpes simplex virus 2 (HHV-2), and pseudorabies virus (PRV) envelope glycoprotein D. PVRL1 functions as an entry receptor for these viruses. Defects in PVRL1 are the cause of ectodermal dysplasia Margarita Island type (EDMI), also known as Zlotogora-Ogur syndrome, cleft lip/palate-ectodermal dysplasia syndrome (CLPED1) or ectodermal dysplasia 4. Defects in PVRL1 are also the cause of non-syndromic orofacial cleft type 7 (OFC7). Non-syndromic orofacial cleft is a common birth defect consisting of cleft lips with or without cleft palate.

References

1. Lopez M. et al., 2001, J Virol. 75: 5684-91.
2. Reymond N. et al., 2001, J Biol Chem. 276: 43205-15.
3. Sakamoto Y. et al., 2006, J Biol Chem. 281:19631-44.
4. Wolf-Yadlin A. et al., 2007, Proc Natl Acad Sci. 104: 5860-5.
5. Heibeck TH. et al., 2009, J Proteome Res. 8: 3852-61.
6. Wollscheid B. et al., 2009, Nat Biotechnol. 27: 378-386.

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