Rat REG4 Protein (His Tag)

Produkt-Information von REG4 Protein

QC Testing von REG4 Protein

Purity	> 78 % as determined by SDS-PAGE	SDS-PAGE: REG4 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Asp 23
Molecular Mass	The recombinant rat REG4 comprises 146 amino acids and predicts a molecular mass of 17.3 kDa. The apparent molecular mass of  the recombinant protein is approximately 26-30 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von REG4 Protein

Verwandte Produkte & Themen von REG4 Protein

Immunology>>Adhesion Molecule>>Lectin>>REG4

Cancer>>Cancer Biomarkers>>REG4

Beschreibung von REG4 Protein

Regenerating islet-derived protein 4, also known as REG-like protein, REG4, GISP and RELP, is a secreted protein which contains one C-type lectin domain. REG4 is involved in inflammatory and metaplastic responses of the gastrointestinal epithelium. REG4 is highly expressed in the gastrointestinal tract including the duodenum, jejunum, ileum, ileocecum, appendix, descending colon, pancreas and small intestine. It is weakly expressed in normal colon and stomach and strongly expressed in most colorectal tumors than in normal colon. It is also preferentialy expressed in mucinous tumors and in some cases neuro-endocrine tumors. REG4 protein overexpression is associated with an unfavorable response to preoperative chemoradiotherapy and may be used as a predictive biomarker clinically. REG4 is also a promising tumor marker to screen early-stage Pancreatic ductal adenocarcinoma (PDAC), and neutralization of REG4 by the antibody may offer novel potential tools for the treatment of PDAC.

References

1. Hartupee JC. et al., 2001, Biochim Biophys Acta. 1518: 287-93.
2. Violette S. et al., 2003, Int J Cancer 103: 185-93.
3. Kaemaeraeinen M. et al., 2003, Am J Pathol. 163: 11-20.
4. Takehara A. et al., 2006, Cancer Sci. 97 (11): 1191-7.
5. Eguchi H. et al., 2009, Pancreas. 38 (7): 791-8.

Sino Biological Inc. liefert Rat REG4 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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