Rat ALCAM / CD166 Protein (His Tag)

Produkt-Information von ALCAM / CD166 Protein

QC Testing von ALCAM / CD166 Protein

Purity	> 98 % as determined by SDS-PAGE	SDS-PAGE: ALCAM / CD166 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Trp 28
Molecular Mass	The recombinant rat ALCAM comprises 511 amino acids and predicts a molecular mass of 57.5 kDa. The apparent molecular mass of  the recombinant protein is approximately 68-91 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von ALCAM / CD166 Protein

Verwandte Produkte & Themen von ALCAM / CD166 Protein

Stem Cell>>Neural Stem Cell (NSC)>>Neuronal Cell Markers>>CD166/ALCAM

Stem Cell>>Mesenchymal Stem Cell (MSC)>>Osteoblast & Osteoclast Marker>>CD166/ALCAM

Stem Cell>>Mesenchymal Stem Cell (MSC)>>Mesenchymal Stem Cell Marker>>CD166/ALCAM

Cancer>>Cancer Stem Cell (CSC)>>CD166/ALCAM

Immunology>>Adaptive Immunity>>T Cell>>T Cell Migration/Adhesion>>CD166/ALCAM

Immunology>>Adhesion Molecule>> Cell Adhesion Molecule (IgSF CAM) >>CD166/ALCAM

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Monocyte Markers>>CD166/ALCAM

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>T Cell Migration/Adhesion>>CD166/ALCAM

Beschreibung von ALCAM / CD166 Protein

ALCAM (activated leukocyte cell adhesion molecule) is a type I  membrane glycoprotein and a member of the immunoglobulin superfamily. It is also known as CD166, MEMD, SC-1/DM-GRASP in the chicken, and KG-CAM in the rat. ALCAM / CD166 has five extracellular immunoglobulin-like domains which facilitates heterophilic (ALCAM-CD6) and homophilic (ALCAM-ALCAM) cell-cell interactions. While expressed in a wide variety of tissues and cells, ALCAM is restricted to subsets of cells usually involved in dynamic growth and / or migration processes. ALCAM is highly associated not only with embryonic hematopoiesis but also vasculoangiogenesis. ALCAM can bind itself homotypically and is also capable of binding CD6, NgCAM, and other unidentified brain proteins, and thus is Involved in neurite extension by neurons via heterophilic and homophilic manners. ALCAM / CD6 interaction plays a role in T cell development and T cell regulation, as well as in the binding of T- cells and B-cells to activated leukocytes. Further, ALCAM has also been observed to be upregulated on highly metastasizing melanoma cell lines, suggesting a role in tumor migration.

References

1. Bowen, M. A. et al., 1995, J. Exp. Med. 181:2213-2220.
2. Aruffo, A. et al., 1997, Immunol. Today. 18: 498-504.
3. Degen, W. G. et al., 1998, Am. J. Pathol. 152: 805-813.
4. Van, K. L. et al., 2001, J. Biol. Chem. 276: 25783-257890.
5. Hirata, H. et al., 2006, Cells Tissues Organs. 184 (3-4):172-180.
6. Jezierska, A. et al., 2006, Med Sci Monit.12 (7): BR245-256.

Sino Biological Inc. liefert Rat ALCAM / CD166 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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