Cynomolgus EphB6 / EPHB6 Protein

Sino Biological Inc. liefert Cynomolgus EphB6 / EPHB6 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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Produkt-Information von EphB6 / EPHB6 Protein

QC Testing von EphB6 / EPHB6 Protein

Purity	> 85 % as determined by SDS-PAGE	SDS-PAGE: EphB6 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Leu 32
Molecular Mass	The recombinant cynomolgus EPHB6 is a disulfide-linked homodimer. The reduced monomer comprises 801 amino acids and has a calculated molecular mass of 86.9 KDa.The apparent molecular mass of the protein is approximately 97 KDa respectively in SDS-PAGE.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von EphB6 / EPHB6 Protein

Verwandte Produkte & Themen von EphB6 / EPHB6 Protein

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>EphB6

Neuroscience>>Axon Guidance>>Ephrin & Eph Receptor>>EphB6

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>EphB6

Cancer>>Growth Factor & Receptor>>Ephrin & Eph Receptor>>EphB6

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>EphB6

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>EphB6

Beschreibung von EphB6 / EPHB6 Protein

Ephrins are divided into the ephrin-A (EFNA) class and the ephrin-B (EFNB) class based on their structures and sequence relationships. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family, and EphB6 binding to ephrin-B ligands is a unique member in that its kinase domain contains several alterations in conserved amino acids and is catalytically inactive. It is indicated that activated by an Src family kinase, EphB6 can act as both positive and negative regulators in the process of cell adhesion and migration,The large family of Ephrin receptors and their ligands , the ephrins , mediate numerous developmental processes, particularly the establishment of regional pattern in the nervous system. Furthermore, the Eph receptors have been suggested to play important roles in tumor formation, prognosis, and possible gene-therapeutic approaches, and the reduction of EphB6 gene expression is associated with the progression of metastatic diseases.

References

1. Flanagan JG. et al., 1998, Annu Rev Neurosci. 21: 309-45.
2. Matsuoka H. et al., 2005, J Biol Chem. 280: 29355-63.
3. Holder N. et al., 1999, Development. 126: 2033-44.
4. Cheng N. et al., 2002, Cytokine Growth Factor Rev. 13: 75-85.
5. Hafner C. et al., 2003, Int J Oncol. 23: 1553-9.
6. Fox BP. et al., 2006, Biochem Biophys Res Commun.340: 268-76.