Rat Nectin-2 / PVRL2 Protein (His Tag)

Sino Biological Inc. liefert Rat Nectin-2 / PVRL2 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat Nectin-2 / PVRL2 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/Nectin-2-PVRL2-Protein-(His-Tag)-g-9895.html

Produkt-Information von Nectin-2 / PVRL2 Protein

QC Testing von Nectin-2 / PVRL2 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: Nectin-2 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gln 32
Molecular Mass	The recombinant rat PVRL2 comprises 331 amino acids and predicts a molecular mass of 36 kDa. The apparent molecular mass of  the recombinant protein is approximately 46 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von Nectin-2 / PVRL2 Protein

Verwandte Produkte & Themen von Nectin-2 / PVRL2 Protein

Cardiovascular>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>CD112/Nectin-2

Neuroscience>>Synaptic Protein>>CD112/Nectin-2

Stem Cell>>Neural Stem Cell (NSC)>>Neuronal Cell Markers>>CD112/Nectin-2

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>CD112/Nectin-2

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>CD112/Nectin-2

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>> CD112/Nectin-2

Immunology>>Innate Immunity>>Natural Killer Cell (NK Cell)>>CD112/Nectin-2

Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Granulocyte Markers>>CD112/Nectin-2

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Monocyte Markers>>CD112/Nectin-2

Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>>CD112/Nectin-2

Beschreibung von Nectin-2 / PVRL2 Protein

Poliovirus receptor-related 2 (PVRL2), also known as Nectin-2 and CD112, is a single-pass type I  transmembrane glycoprotein belonging to the nectin family, and structurally comprises two Ig-like C2-type domains and one Ig-like V-type domain in the extracellular region. Mouse CD112 is a 70 to 78 kDa type I  TM glycoprotein that is found on a variety of cell types. As a homophilic adhesion molecule, CD112 is widely expressed in human tissues including hematopoietic cells and mediates intercellular junctions of adjacent cells. CD112 has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 can induce NK cell- and CD8+T cell-mediated cytotoxicity and cytokine secretion. CD112 protein serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and is involved in cell to cell spreading of these viruses. Disruption of both alleles of the murine CD112 gene resulted in morphologically aberrant spermatozoa. CD112 has also been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy. Mouse CD112 ECD shares 72%, 77%, 95% aa identity with the ECD in human, canine and rat CD112, respectively.

References

1. Lopez M. et al., 1998, Blood. 92: 4602-11.
2. Cocchi F. et al., 2000, J Virol. 74: 3909-17.
3. Peng YF. et al., 2002, Oncogene. 21: 4108-19.
4. Tahara HS. et al., 2005, Biochem Biophys Res Commun. 329: 996-1000.
5. Bachelet I. et al., 2006, J Biol Chem. 281: 27190-6.
6. Wang, L. et al., 2009, Vet Immunol Immunopathol.