Rat CD79B / B29 Protein

Sino Biological Inc. liefert Rat CD79B / B29 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat Rat CD79B / B29 Protein lesen Sie bitte: http://www.sinobiological.com/CD79B-B29-Protein-g-9894.html

Produkt-Information von CD79B / B29 Protein

QC Testing von CD79B / B29 Protein

Purity	> 90% as determined by SDS-PAGE	SDS-PAGE: CD79B protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Val 26
Molecular Mass	The recombinant rat CD79B/Fc is a disulfide-linked homodimer. The reduced monomer comprises 374 amino acids and has a predicted molecular mass of 42.2 kDa. The apparent molecular mass of the protein is approximately 50 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CD79B / B29 Protein

Verwandte Produkte & Themen von CD79B / B29 Protein

Immunology>>Adaptive Immunity >>B Cell>>CD79B

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD79B

Beschreibung von CD79B / B29 Protein

B-cell antigen receptor complex-associated protein beta chain, also known as B-cell-specific glycoprotein B29, Ig-beta, Immunoglobulin-associated B29 protein, CD79b and B29, is a single-pass type I membrane protein which contains one Ig-like V-type ( immunoglobulin-like ) domain and one ITAM domain. CD79b / B29 is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. CD79b / B29 enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79b / B29 are the cause of agammaglobulinemia type 6 (AGM6) which is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development.

References

1. Mueller BS. et al., 1992, Eur J Immunol. 22: 1621-5.
2. Wood WJ. et al., 1993, Genomics. 16: 187-92.
3. Hashimoto S. et al., 1994, Immunogenetics. 40: 145-9.
4. Radaev S. et al., 2010, Structure. 18: 934-43.
5. Burkard TR. et al., 2011, BMC Syst Biol. 5: 17-17.