Rat BST-1 / BST1 Protein

Sino Biological Inc. liefert Rat BST-1 / BST1 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat BST-1 / BST1 Protein lesen Sie bitte: http://www.sinobiological.com/BST-1-BST1-Protein-g-9896.html

Produkt-Information von BST-1 / BST1 Protein

QC Testing von BST-1 / BST1 Protein

Purity	> 95% as determined by SDS-PAGE	SDS-PAGE: BST-1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ala 28
Molecular Mass	The recombinant rat BST1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 506 amino acids and has a predicted molecular mass of 56.8 kDa. The apparent molecular mass of the protein is approximately 67 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von BST-1 / BST1 Protein

Verwandte Produkte & Themen von BST-1 / BST1 Protein

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD157/BST1

Beschreibung von BST-1 / BST1 Protein

CD157, also known as bone marrow sromal cell antigen 1 (BST-1), is a glycosylphosphatidylinositol-anchored ectoenzyme belonging to the NADase/ADP-ribosyl cyclase family. It is expressed in the bone marrow, spleen and thymus in lymphoid organs, and the lung, kidney and heart in non-lymphoid organs. In mouse, CD157 is also expressed on lymphoid progenitors. It has a dual nature behaving both as an ectoenzyme and as a receptor. Cross-linking of CD157 induces intracellular Ca2+ mobilization and re-shaping in neutrophils, thus regulating their adhesive and migratory properties. The CD157-mediated signals promote cell polarization, regulate chemotaxis induced through the high affinity formyl-methionyl-leucyl-phenylalanine (fMLP) receptor and control transendothelial migration. CD157 exhibits homology with CD38 and Aplysia ADP-ribosyl cyclase. Like CD38, it has both ADP-ribosyl cyclase and cADPR hydrolase activities. The CD157 gene is synthenic on 4p15 with CD38, with which it also shares a unique genomic organization. Their conservation in phylogeny is striking evidence for their relevance in the life and death cycle of the cell. CD157 has a specific and crucial role in the regulation of innate immunity during inflammation. The murine CD157 is a useful marker for lymphoid progenitor cells initiating gene rearrangement of their antigen receptors.

References

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4. Ortolan E. et al., 2002, Cell Biochem Funct. 20(4): 309-22.
5. Funaro A. et al., 2004, Blood. 104 (13): 4269-78.
6. Lavagno L. et al., 2007, J Biol Regul Homeost Agents. 21 (1-2): 5-11.
7. Funaro A. et al., 2009, Front Biosci. 14: 929-43.