Rat N-cadherin / Cadherin 2 / CDH2 Protein (His Tag)

Sino Biological Inc. liefert Rat N-cadherin / Cadherin 2 / CDH2 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat N-cadherin / Cadherin 2 / CDH2 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/N-cadherin-Cadherin-2-CDH2-Protein-g-10274.html

Produkt-Information von N-cadherin / Cadherin 2 / CDH2 Protein

QC Testing von N-cadherin / Cadherin 2 / CDH2 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: N-cadherin protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ser 26
Molecular Mass	The recombinant rat CDH2 comprises 710 amino acids and predicts a molecular mass of 78.4 kDa. The apparent molecular mass of  the recombinant protein is approximately 44-53 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von N-cadherin / Cadherin 2 / CDH2 Protein

Verwandte Produkte & Themen von N-cadherin / Cadherin 2 / CDH2 Protein

Neuroscience>>Synaptic Protein>>N-Cadherin/CDH2/CD325

Stem Cell>>Mesenchymal Stem Cell (MSC)>>Mesenchymal Stem Cell Marker>>N-Cadherin/CDH2/CD325

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>N-Cadherin/CDH2/CD325

Immunology>>Adhesion Molecule>> Cadherin>>N-Cadherin/CDH2/CD325

Immunology>>Cluster of Differentiation>>N-Cadherin/CDH2/CD325

Beschreibung von N-cadherin / Cadherin 2 / CDH2 Protein

Cadherins are calcium dependent cell adhesion proteins, and they preferentially interact with themselves in a homophilic manner in connecting cells. Human cadherin 2, type 1, N-cadherin (neuronal) (NCAD) , also known as CDH2, is a single-pass tranmembrane protein and a cadherin containing 5 cadherin domains. N-cadherin displays a ubiquitous expression pattern but with different expression levels between endocrine cell types. CDH2 (NCAD) has been shown to play an essential role in normal neuronal development, which is implicated in an array of processes including neuronal differentiation and migration, and axon growth and fasciculation. In addition, N-cadherin expression was upregulated in human HSC during activation in culture, and function or expression blocking of N-cadherin promoted apoptosis. During apoptosis, N-cadherin was cleaved into 20-100 kDa fragments. N-cadherin cleavage occurred at a higher level in glioblastoma cells than in non-neoplastic astrocytes.

References

1. LaMora A. et al., 2009, Neuroscience. 159: 1175-84
2. Chauvet N. et al., 2009, J Endocrinol. 202: 375-87.
3. Hartland S.N. et al., 2009, Liver Int. 29: 966-78.
4. Kohutek Z.A. et al., 2009, J Neurosci. 29: 4605-15.