Rat E-cadherin / CDH1 / Cadherin-1 Protein

Sino Biological Inc. liefert Rat E-cadherin / CDH1 / Cadherin-1 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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Produkt-Information von E-cadherin / CDH1 / Cadherin-1 Protein

QC Testing von E-cadherin / CDH1 / Cadherin-1 Protein

Purity	> 75 % as determined by SDS-PAGE	SDS-PAGE: E-cadherin protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gln 24
Molecular Mass	The recombinant rat CDH1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 931 amino acids and has a predicted molecular mass of 103.8 kDa. The apparent molecular mass of the protein is approximately 116 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von E-cadherin / CDH1 / Cadherin-1 Protein

Verwandte Produkte & Themen von E-cadherin / CDH1 / Cadherin-1 Protein

Cardiovascular>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>E-Cadherin/CDH1/CD324

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Hemangioblast Marker>>E-Cadherin/CDH1/CD324

Stem Cell>>Embryonic Stem Cell (ESC)>>Embryonic Stem Cell Marker>>E-Cadherin/CDH1/CD324

Cancer>>Cancer Stem Cell (CSC)>>E-Cadherin/CDH1/CD324

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>E-Cadherin/CDH1/CD324

Cancer>>Cancer Biomarkers>>E-Cadherin/CDH1/CD324

Immunology>>Adhesion Molecule>> Cadherin>>E-Cadherin/CDH1/CD324

Immunology>>Innate Immunity>>Natural Killer Cell (NK Cell)>>E-Cadherin/CDH1/CD324

Immunology>>Cluster of Differentiation>>Other>>E-Cadherin/CDH1/CD324

Beschreibung von E-cadherin / CDH1 / Cadherin-1 Protein

Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadherin (E-Cad), also known as CDH1 and CD324, is the classical cadherin molecule and contains five cadherin domains of ~110 aa each in the extracellular domain. E-Cad is expressed in the non-neural epithelial tissues as disulfide-linked homodimer, and plays a key role in the organization and integrity of most epithelial tissues, cell differentiation and tissue development. CDH1 interacts directly, via the cytoplasmic domain, with CTNNB1 or JUP to form the PSEN1/cadherin/catenin adhesion complex which connects to the actin skeleton through the actin binding of alpha-catenin. During apoptosis or with calcium influx, E-Cad is cleaved by the metalloproteinase to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. E-Cad has been identified as a potent invasive suppressor, as downregulation of E-cadherin expression is involved in dysfunction of the cell-cell adhesion system, and often correlates with strong invasive potential and poor prognosis of human carcinomas (gastric, breast, ovary, endometrium and thyroid).

References

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2. Yoshiura K. et al., 1995, Proc. Natl. Acad. Sci. 92: 7416-9.
3. Becker K-F. et al., 1994, Cancer Res. 54: 3845-52.
4. Marambaud P. et al., 2002, EMBO J. 21: 1948-56.
5. Steinhusen U. et al., 2001, J Biol Chem. 276: 4972-80.