Cynomolgus CCL17 / TARC Protein (His Tag)

Sino Biological Inc. liefert Cynomolgus CCL17 / TARC Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Cynomolgus CCL17 / TARC Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/CCL17-TARC-Protein-g-10278.html

Produkt-Information von CCL17 / TARC Protein

QC Testing von CCL17 / TARC Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: CCL17 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ala 24
Molecular Mass	The recombinant heterodimer of cynomolgus CCL17 comprises 81 amino acids and has a calculated molecular mass of 9.5 KDa. The apparent molecular mass of the protein is approximately 10 KDa respectively in SDS-PAGE.
Formulation	Lyophilized from sterile 20mM Tris, 500mM NaCl,  pH 7.4, 10% gly. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CCL17 / TARC Protein

Verwandte Produkte & Themen von CCL17 / TARC Protein

Immunology>>Cytokine & Receptor>>Chemokine & Receptor>>CCL17/TARC

Immunology>>Innate Immunity>>Monocyte/Macrophage>>Macrophage Marker>>CCL17/TARC

Beschreibung von CCL17 / TARC Protein

C-C motif chemokine 17, also known as CC chemokine TARC, Small-inducible cytokine A17, Thymus and activation-regulated chemokine, CCL17 and SCYA17, is a secreted protein which belongs to the intercrine beta (chemokine CC) family. Chemokines are known to regulate the steady-state and inflammatory migration of cutaneous dendritic cells (DCs). The beta-chemokine CCL17, a ligand of CCR4, is inducibly expressed in a subset of DCs and is strongly up-regulated in atopic diseases. CCL17 / SCYA17 is constitutively expressed in the thymus and is produced by dendritic cells (DC), endothelial cells, keratinocytes (KC) and fibroblasts. CCL17 / SCYA17 is expressed at high levels in thymus and at low levels in the lung, colon and small intestine. CCL17 / SCYA17 is a chemotactic factor for T-lymphocytes but not monocytes or granulocytes. It may play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. CCL17 / SCYA17 binds to CCR4.Chemokine receptor CCR4 and its ligands (CCL17 and CCL22) are important for the recruitment of memory T cells into the skin in various cutaneous immune disease.

References

1. Belperio JA. et al., 2004, J Immunol. 173 (7): 4692-8.
2. Carpenter KJ. et al., 2005, Infect Immun. 73 (11): 7198-207.
3. Saeki H. et al., 2006, J Dermatol Sci. 43 (2): 75-84.
4. Niens M. et al., 2008, Br J Haematol. 140 (5): 527-36.
5. Stutte S. et al., 2010, Proc Natl Acad Sci. 107 (19): 8736-41.