Rat MSR1 / SCARA1 Protein

19.12.2012

Sino Biological Inc. liefert Rat MSR1 / SCARA1 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat MSR1 / SCARA1 Protein Protein lesen Sie bitte: http://www.sinobiological.com/MSR1-SCARA1-Protein-g-10048.html

Produkt-Information von MSR1 / SCARA1 Protein

Synonym	MSR1
Protein Construction	A DNA sequence encoding the rat MSR1 (Trp79-Ser454) was expressed, fused with the Fc region of human IgG1 at the N-terminus.
Source	Rat
Expression Host	Human Cells

QC Testing von MSR1 / SCARA1 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: MSR1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu
Molecular Mass	The recombinant Rat MSR1/Fc comprises 636 amino acids and has a predicted molecular mass of 69.2 kDa. The apparent molecular mass of the protein is approximately 89 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von MSR1 / SCARA1 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Verwandte Produkte & Themen von MSR1 / SCARA1 Protein

Related Areas:

Immunology>>Innate Immunity>>Monocyte/Macrophage>>Scavenger Receptor>>MSR1/CD204

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers>>MSR1/CD204

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
MSR1/CD204/SCARA1	Human	MSR1/CD204 Protein, Recombinant	10427-H07H
MSR1/CD204/SCARA1	Mouse	MSR1/CD204 Protein, Recombinant	50129-M07H
MSR1/CD204/SCARA1	Rat	MSR1 / SCARA1 Protein, Recombinant	80363-R01H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human MSR1/CD204/SCARA1	WB, ELISA	MSR1/CD204 Antibody, Mouse MAb	10427-MM02
Human MSR1/CD204/SCARA1	WB, ELISA	MSR1/CD204 Antibody, Rabbit MAb	10427-R005
Mouse MSR1/CD204/SCARA1	WB, ELISA	MSR1 / CD204 Antibody	50129-RP01
Mouse MSR1/CD204/SCARA1	WB, ELISA	MSR1 / CD204 Antibody (Antigen Affinity Purified)	50129-RP02
Human MSR1/CD204/SCARA1	FCM	MSR1 / CD204 Antibody ( FITC )	50129-R004-F

Beshcreibung von MSR1 / SCARA1 Protein

Macrophage scavenger receptor types I and II, also known as Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD204, MSR1 and SCARA1, is a single-pass type I I membrane protein which contains one collagen-like domain and one SRCR domain. Macrophages are distributed in all peripheral tissues and play a critical role in the first line of the innate immune defenses against bacterial infection by phagocytosis of bacterial pathogens through the macrophage scavenger receptor 1 (MSR1). MSR1 / SCARA1 is one of the membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). MSR1 / SCARA1 is also involved in chronic inflammation which is a risk factor for prostate cancer. MSR1 1 gene was identified as a candidate susceptibility gene for hereditary prostate cancer and as a risk factor for sporadic prostate cancer.

References

Wang L. et al., 2003, Nat Genet. 35 (2): 128-9.
Chen Y.C. et al., 2008, Cancer Epidemiol Biomarkers Prev. 17 (4): 1001-3.
Shirato K. et al., 2009, Pflugers Arch. 459 (1): 93-103.
Sun J. et al., 2006, Prostate. 66 (7): 728-37.