Rat MBL1 Protein

27.04.2013

Sino Biological Inc. liefert Rat MBL1 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat MBL1 Protein lesen Sie bitte: http://www.sinobiological.com/MBL1-Protein-g-11615.html

Produkt-Information von MBL1 Protein

Synonym	MBL1
Protein Construction	A DNA sequence encoding the rat MBL1 (P19999) (Met1-Ala238) was expressed with the Fc region of human IgG1 at the C-terminus.
Source	Rat
Expression Host	Human Cells

QC Testing von MBL1 Protein

Purity	> 85% as determined by SDS-PAGE	SDS-PAGE: MBL1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ser 18
Molecular Mass	The recombinant rat MBL1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 462 amino acids and has a predicted molecular mass of 50.5 kDa. The apparent molecular mass of the protein is approximately 56 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von MBL1 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von MBL1 Protein

Mannose binding lectin (MBL), also named mannose or mannan-binding protein (MBP), belongs to the class of collectins in the C-type lectin superfamily. Its function appears to be pattern recognition in the first line of defense in the pre-immune host. MBL recognizes carbohydrate patterns found on the surface of a large number of pathogenic micro-organisms including bacteria, viruses, protozoa and fungi. Binding of MBL to a micro-organism results in activation of the lectin pathway of the complement system. Two forms of MBL, MBL-A and MBL-C, were characterized in rodents, rabbits, bovine and rhesus monkeys, whereas only one form was identified in humans, chimpanzees and chickens. The two forms are encoded by two distinct genes named MBL1 and MBL2, which have been identified in many species. Mouse MBL1, also known as MBL-A , contains one C-type lectin domain and one collagen-like domain, and is located intracellular, most predominantly in the rough endoplasmic reticulum.

References

Sastry R. et al., 1995, Mamm Genome. 6 (2): 103-110.
Lillie B. N. et al., 2006, Immunogenetics. 58 (12): 983-993.
Phatsara C. et al., 2007, Int J Immunogenet. 34 (1): 55-63.